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AR / Androgen Receptor

androgen receptor

The androgen receptor (AR) is a NR3 Steroid Receptor located on the X chromosome. AR is a phosphoprotein and acts as a steroid hormone-activated transcription factor for androgen-responsive genes. Mutations in the AR gene are associated with androgen insensitivity syndrome (CAIS) or testicular feminization syndrome, Reifenstein syndrome, and Kennedy spinal and bulbar muscular atrophy. They lead to symptoms such as low virilization, reduced sperm production, testicular atrophy, and infertility. Androgen signaling through the androgen receptor (AR) appears to be involved in all aspects of prostate cancer, from initiation to development of treatment resistance. Gain-of-function AR gene mutations and/or altered signaling through AR have been suggested to contribute to disease progression. A recent study showed decreased expression of AR in response to incubation of LNCaP prostate carcinoma cells with PC-SPES, a mixture of eight herbs (Bonham et al. 2002). Two forms of AR that differ in their N termini have been isolated: AR A (87 kD), which is derived from translation of an internal methionine codon (met188), and AR B (110 kD). The two isoforms are expressed in similar tissues; however, AR B generally is the more abundant form.

Gene Name: androgen receptor
Family/Subfamily: NHR , NR3 Steroid receptor
Synonyms: AR, Androgen receptor, Dihydrotestosterone receptor, DHTR, AIS, KD, NR3C4, HUMARA, SBMA, TFM, SMAX1, HYSP1
Target Sequences: NM_000044 NP_000035.2 P10275

Publications (3)

1
Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer. Gonzalez-Angulo AM, Stemke-Hale K, Palla SL, Carey M, Agarwal R, Meric-Berstam F, Traina TA, Hudis C, Hortobagyi GN, Gerald WL, Mills GB, Hennessy BT. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:2472-8. [PubMed:19276248]
2
Abnormal mitochondrial function and impaired granulosa cell differentiation in androgen receptor knockout mice. Wang RS, Chang HY, Kao SH, Kao CH, Wu YC, Yeh S, Tzeng CR, Chang C. International journal of molecular sciences. 2015 16:9831-49. (ICC; Human) [Full Text Article] [PubMed:25941928] [PMC:PMC4463620]
3
ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor. Mounir Z, Korn JM, Westerling T, Lin F, Kirby CA, Schirle M, McAllister G, Hoffman G, Ramadan N, Hartung A, Feng Y, Kipp DR, Quinn C, Fodor M, Baird J, Schoumacher M, Meyer R, Deeds J, Buchwalter G, Stams T, Keen N, Sellers WR, Brown M, Pagliarini RA. eLife. 2016 5: (WB; Human) [Full Text Article] [PubMed:27183006] [PMC:PMC4909395] Related Antibodies: LS-C87494.

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Products
Antibodies (214)
Primary (214)
AR / Androgen Receptor (214)
Human (187)
Mouse (48)
Rat (59)
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Chimpanzee (3)
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rabbit (141)
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AR / Androgen Receptor Antibody - Formalin-fixed, paraffin-embedded human prostate stained with peroxidase-conjugate and DAB chromogen. Note nuclear staining of glandular epithelial cells.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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AR / Androgen Receptor Mouse anti-Human Monoclonal (AR 441) Antibody
Dog, Human
GS, IF, IHC, IHC-P, IP, WB
Unconjugated
1 ml/$910
AR / Androgen Receptor Antibody - Immunohistochemistry of Human Prostate Adenocarcinoma stained with anti-Androgen Receptor (AR) antibody
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AR / Androgen Receptor Rabbit anti-Human Monoclonal (N-Terminus) (SP107) Antibody
Human
IHC, IHC-P
Unconjugated
500 µl/$538
AR / Androgen Receptor Antibody - Immunohistochemistry of Human prostate adenocarcinoma stained with anti-AR (C-term) antibody
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AR / Androgen Receptor Rabbit anti-Human Monoclonal (C-Terminus) (SP242) Antibody
Human
IHC, IHC-P
Unconjugated
500 µl/$552
AR / Androgen Receptor Antibody - Androgen Receptor Antibody (2µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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AR / Androgen Receptor Goat anti-Human Polyclonal (aa2-16) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µg/$451
AR / Androgen Receptor Antibody - Anti-Androgen Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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AR / Androgen Receptor Mouse anti-Human Monoclonal (2H8) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$440
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (pTyr267) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$485
AR / Androgen Receptor Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (aa611-660) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
AR / Androgen Receptor Antibody - Immunoperoxidase of monoclonal antibody to AR on formalin-fixed paraffin-embedded human renal cell carcinoma tissue. [antibody concentration 3 ug/ml].
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AR / Androgen Receptor Mouse anti-Human Monoclonal (1G3) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$407
AR / Androgen Receptor Antibody - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor antibody (AR441 + DHTR/882).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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AR / Androgen Receptor Mouse anti-Human Monoclonal (aa300-316) (AR441 + DHTR/882) Antibody
Human
IF, IHC, IHC-P
Unconjugated
20 µg/$340; 100 µg/$501
AR / Androgen Receptor Antibody - Immunohistochemical analysis of Androgen Receptor (pS650) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (pSer650) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$289
AR / Androgen Receptor Antibody - Immunohistochemistry of paraffin-embedded mouse brain tissue.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
AR / Androgen Receptor Antibody - Immunohistochemical analysis of Androgen Receptor staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$311
AR / Androgen Receptor Antibody - Detection of Human Androgen Receptor by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Androgen Receptor used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC, IP, WB
Unconjugated
100 µl/$457
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$767
AR / Androgen Receptor Antibody - Immunofluorescence analysis of HeLa cells, using Androgen Receptor (Phospho-Ser94) Antibody. The picture on the right is blocked with the phospho peptide.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (pSer94) Antibody
Mouse, Human
IF, Peptide-ELISA
Unconjugated
50 µl/$306; 100 µl/$366
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AR / Androgen Receptor Mouse anti-Human Monoclonal (aa660-919) (TS106) Antibody
Human
IHC
Unconjugated
100 µg/$716
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AR / Androgen Receptor Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$771
AR / Androgen Receptor Antibody - Anti-Androgen Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (aa621-670) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
AR / Androgen Receptor Antibody - Western blot of recombinant AR / Androgen Receptor.
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AR / Androgen Receptor Rabbit anti-Mouse Polyclonal (aa156-310) Antibody
Mouse
WB
Unconjugated
100 µl/$297; 200 µl/$338; 500 µl/$475; 1 ml/$543
AR / Androgen Receptor Antibody - Immunohistochemical analysis of Androgen Receptor (pS213) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (pSer213) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$253; 100 µl/$305; 200 µl/$369
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AR / Androgen Receptor Mouse anti-Human Monoclonal (aa661-920) (APC) (11n6) Antibody
Human
Flo
APC Conjugated
100 Tests/$777
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AR / Androgen Receptor Mouse anti-Human Monoclonal (aa661-920) (PE) (11n6) Antibody
Mouse, Rat, Human
Flo
PE Conjugated
100 Tests/$716
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AR / Androgen Receptor Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
0.1 ml/$320; 0.5 ml/$532; 1 ml/$819
AR / Androgen Receptor Antibody - Immunohistochemistry-Paraffin: Androgen Receptor Antibody (2H8) - Immunohistochemical analysis of paraffin-embedded human Prostate tissues using Androgen Receptor mouse mAb.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AR / Androgen Receptor Mouse anti-Human Monoclonal (2H8) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 ml/$376
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (aa870-920) Antibody
Human
IP
Unconjugated
100 µl/$457
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).