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Catalog Number Size Price
LS-C387996-100 100 µg $480 
APP / Beta Amyloid Precursor Antibody - IHC-P: APP antibody testing of rat brain tissue
APP / Beta Amyloid Precursor Antibody - Western blot testing of APP antibody and Lane 1: rat brain; 2: human HeLa. The glycoprotein is visualized between ~87KD (immature) and ~120KD (mature).
APP / Beta Amyloid Precursor Antibody - IHC-P: APP antibody testing of rat brain tissue
APP / Beta Amyloid Precursor Antibody - Western blot testing of APP antibody and Lane 1: rat brain; 2: human HeLa. The glycoprotein is visualized between ~87KD (immature) and ~120KD (mature).
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Polyclonal Rabbit anti‑Human APP / Beta Amyloid Precursor Antibody (aa19‑33, IHC, WB) LS‑C387996

Polyclonal Rabbit anti‑Human APP / Beta Amyloid Precursor Antibody (aa19‑33, IHC, WB) LS‑C387996

Antibody:
APP / Beta Amyloid Precursor Rabbit anti-Human Polyclonal (aa19-33) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Pig, Rabbit, Sheep
Format:
Unconjugated, Unmodified
Price
Catalog Number
$480
LS-C387996-100
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
APP / Beta Amyloid Precursor Rabbit anti-Human Polyclonal (aa19-33) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Pig, Rabbit, Sheep
Format:
Unconjugated, Unmodified

Specifications

Description
Beta Amyloid Precursor antibody LS-C387996 is an unconjugated rabbit polyclonal antibody to Beta Amyloid Precursor (APP) (aa19-33) from human. It is reactive with human, mouse, rat and other species. Validated for IHC and WB.
Target
Human APP / Beta Amyloid Precursor
Synonyms
APP | ABPP | A4 | ABETA | AD1 | Alzheimer disease | Amyloid beta | Beta-amyloid peptide | APPI | Beta amyloid | CVAP | AAA | PN2 | PreA4 | Amyloid beta A4 protein | Peptidase nexin-II | CTFgamma | PN-II | Protease nexin-II
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Pig, Rabbit, Sheep (tested or 100% immunogen sequence identity)
Predicted
Chicken (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic peptide from the N-Terminus of human Amyloid beta (EVPTDGNAGLLAEPQ, aa19-33 of UniProt P05067). Percent identity by BLAST analysis: Human, Mouse, Rat, Ferret, Sheep, Bovine, Bat, Rabbit, Pig, Guinea pig, Lizard, Dog (100%); Chicken, Platypus (93%).
Epitope
aa19-33
Specificity
Human APP / Beta Amyloid Precursor
Applications
  • IHC
  • IHC - Paraffin (0.5 - 1 µg/ml)
  • Western blot (0.5 - 1 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Amyloid precursor protein is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and iron export. APP is best known and most commonly studied as the precursor molecule whose proteolysis generates Amyloid beta (Abeta), a 39- to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimers disease patients. The protein undergoes posttranslational proteolytic processing by alpha-, beta-, and gamma-secretases. Alpha-secretase generates soluble amyloid protein, while beta- and gamma-secretases generate APP components with amyloidogenic features. These two processing pathways are mutually exclusive.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
Reconstitution
Reconstitute in sterile distilled water.
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About APP / Beta Amyloid Precursor
P05067 NM_000484 NP_000475.1

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 12/4/2021