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Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.
Gene Name: | Apolipoprotein A-V |
Synonyms: | APOA5, Apo-AV, APOAV, Apolipoprotein A5, Apo-A5, Apolipoprotein A-V, RAP3, ApoA-V |
Target Sequences: | NM_052968 NP_443200.2 Q6Q788 |
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