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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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UCHL1 / PGP9.5 Antibody (clone 31A3) LS‑C11453
PGP9.5 antibody LS-C11453 is an unconjugated mouse monoclonal antibody to PGP9.5 (UCHL1) from human and rat. Validated for ELISA, IHC and WB.
Antibody
Catalog
Size
Price
LS-C11453-200
200 µg (1 mg/ml)
$445

Popular UCHL1 / PGP9.5 Products

Anti-UCHL1 / PGP9.5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5981 dilution 1:200.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Antibody
Species: Human, Mouse, Rat, Bovine, Cat, Dog, Guinea pig, Hamster, Pig, Rabbit, Sheep
Applications: IHC, IHC - Paraffin, Western blot
Anti-UCHL1 / PGP9.5 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3043 dilution 1:100.
Species: Human, Rat
Applications: IHC, IHC - Paraffin
Anti-UCHL1 / PGP9.5 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6518 concentration 10 ug/ml.
Species: Human, Monkey, Dog
Applications: IHC, IHC - Paraffin, Western blot
Anti-UCHL1 / PGP9.5 antibody IHC of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6168 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, ELISA

Product Description

PGP9.5 antibody LS-C11453 is an unconjugated mouse monoclonal antibody to PGP9.5 (UCHL1) from human and rat. Validated for ELISA, IHC and WB.
About UCHL1 / PGP9.5
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity. P09936 NM_004181 NP_004172.2

UCHL1 Antibody, Ubiquitin C-terminal hydrolase Antibody, PARK5 Antibody, PGP9.5 Antibody, PGP95 Antibody, Ubiquitin thioesterase L1 Antibody, Neuron cytoplasmic protein 9.5 Antibody, PGP 9.5 Antibody, Uch-L1 Antibody


Specifications

Target
Human UCHL1 / PGP9.5
Host
Mouse
Reactivity
Human, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [31A3]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:100 - 1:400)
  • Western blot
  • ELISA (1:500 - 1:2000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
UCHL1 / PGP9.5 antibody was raised against native, from brain.
Specificity
Recognizes protein gene product 9.5 (PGP9.5), a ubiquitin hydrolase which is widely expressed in neuronal tissues and represents 1-2% of total soluble brain proteins. PGP9.5, also known as ubiquitin C-terminal hydrolase 1 (UCHL-1), is involved in the regulation of the ubiquitin pathway. Stains neuronal cell bodies and axons in the CNS and periphery, small nerve fibres in peripheral tissues, neuroendocrine cells in the pituitary, thyroid, pancreas and tumors of the DNES. Clones 31A3 and each recognize a different epitope towards the N-terminus of the protein. Also recognizes PGP9.5 in other species, including rat and rabbit but evidence suggests it does not bind to PGP9.5 in guinea pigs. Has been used successfully as a capture reagent with clone 13C4 as a detection reagent in a sandwich ELISA to evaluate contamination of processed meat samples with neuronal tissue.
Presentation
PBS, pH 7.2, 0.09% Sodium Azide
Storage
Store at 4°C or -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/20/2018

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