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Ubiquitin Activating Enzyme (E1), also known as A1S9 and UBE1, is responsible for the first step in ubiquitin-protein isopeptide bond formation. E1 catalyzes the activation of the Cterminal carboxyl group of ubiquitin by forming a high-energy thioester bond in an ATP-dependent manner. UBE1 is monomeric and contains two active sites within the E1 molecule, allowing it to bind two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. Alternative splicing results in 2 transcript variants encoding the same protein, but with different 5' UTR. Isoform 1 has a different 5' noncoding exon compared to isoform 2. Both variants encode the same protein.
Gene Name: | ubiquitin-like modifier activating enzyme 1 |
Synonyms: | UBA1, A1S9, A1ST, A1S9T, AMCX1, GXP1, Protein A1S9, SMAX2, Ubiquitin-activating enzyme E1, UBE1X, POC20, UBE1, UBA1A |
Target Sequences: | NM_003334 NP_003325.2 P22314 |
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