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Anti-TS / Thymidylate Synthase Antibody IHC-plus™ LS-B9494

Note: This antibody replaces LS-C59323

Ordering

Wt. Vol. Conc. Price
- 500 µl - $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular TS / Thymidylate Synthase Antibodies

Anti-TS / Thymidylate Synthase Antibody (clone 2B2) IHC-plus™ LS-B6165
Mouse Monoclonal [clone 2B2] (IgG1,k) to Human TS / Thymidylate Synthase
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated
Immunohistochemistry Image
Anti-TS / Thymidylate Synthase Antibody (clone 10F12) LS-C175645
Mouse Monoclonal [clone 10F12] (IgG2a) to Human TS / Thymidylate Synthase
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-TS / Thymidylate Synthase Antibody (aa263-313) LS-C290647
Rabbit Polyclonal to Human TS / Thymidylate Synthase
Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit
Western blot, Immunoprecipitation
Unconjugated
Western blot Image

100% Guaranteed 100% Guaranteed
Sheep Polyclonal to Human TS / Thymidylate Synthase
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated

Details

Human TS / Thymidylate Synthase
Sheep
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Antiserum
Unmodified

Applications

  • IHC - Paraffin (1:100)
  • Western blot
  • ELISA

Specificity and Use

TS / Thymidylate Synthase antibody was raised against recombinant human Thymidylate Synthase (36 kD) produced in E. coli.
Recognizes human Thymidylate Synthase and is useful in determining its presence in various assays. Because inhibition of Thymidylate Synthase prevents DNA synthesis and cell proliferation, the enzyme is an important target for cancer chemotherapeutic drugs, specifically the fluoropyrimidine group of antineoplastic drugs used to treat solid tumors.
This antiserum against Human Thymidylate Synthase (hTS) has been tested for use in ELISA, immunohistochemistry with FFPE human tissues, and immunoblotting. The antibody recognizes the expected additional band corresponding to the ternary complex of hTS-dFUMP-reduced folate in HeLa cells treated with the TS inhibitor 5-FUdR. This event occurs in most human breast, colorectal, gastric, head and neck carcinomas. The antibody recognizes the 36000 MW hTS.

Packaging

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About TS / Thymidylate Synthase

P04818 NM_001071 NP_001062.1

TYMS Antibody, HST422 Antibody, Thymidylate synthetase Antibody, TMS Antibody, TS Antibody, Thymidylate synthase Antibody, Tsase Antibody

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

Immunohistochemistry

Immunohistochemistry
Anti-TYMS/TS/Thymidylate Synthase antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Western blot

Western blot
Anti-Thymidylate Synthase Antibody - Western Blot. Anti-TS is shown to detect thymidylate synthase present in a HeLa cell extract. Each lane is estimated to contain 4 ug of protein. Lanes 1, 2 and 3 represent 1:2000, 1:5000 and 1:10000 fold dilutions of the antibody. Detection was made using HRP Rabbit-a-Sheep IgG (LS-C61113) diluted 1:1000 and color development using TMB (TMBM-100) substrate for approximately 4.

Requested From: United States
Date Requested: 12/5/2016

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