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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TS / Thymidylate Synthase

thymidylate synthetase

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Gene Name: thymidylate synthetase
Synonyms: TYMS, HST422, Thymidylate synthetase, TMS, TS, Thymidylate synthase, Tsase
Target Sequences: NM_001071 NP_001062.1 P04818

Publications (1)

1
Characterization of a polyclonal antibody to human thymidylate synthase suitable for the study of colorectal cancer specimens. Haqqani AS, Cowling RT, Maroun JA, Birnboim HC. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1999 47:1563-74. [PubMed:10567440]

Filtered by: None
Target
TS / Thymidylate Synthase (102)
Reactivity
Human (102)
Mouse (10)
Rat (15)
Bat (4)
Bovine (4)
Chimpanzee (3)
Gibbon (3)
Hamster (4)
Monkey (1)
Application
IHC (58)
IHC-Fr (4)
IHC-P (33)
WB (81)
Flo (30)
ELISA (47)
ICC (2)
IF (45)
IP (29)
Host
rabbit (26)
mouse (71)
sheep (5)
Isotype
IgG (18)
IgG1 (30)
IgG1,k (29)
IgG2a (7)
IgG2b (3)
IgG2b,k (1)
Clonality
monoclonal mc (71)
polyclonal pc (31)
Clone
10F12 (1)
1A3 (1)
1A6 (1)
1B1 (1)
1B2 (1)
1C3 (1)
1C4 (1)
1C5 (1)
1D6 (1)
1E12 (1)
2B2 (1)
2C3 (1)
2C5 (1)
2D8.D11 (1)
3A1 (1)
3A7.A11 (1)
3F1 (1)
4G10 (1)
5H8 (1)
9H4 (1)
SPM453 (2)
TMS715 (3)
TS 106 (2)
TS106 (5)
TS106 + TMS715 (3)
TYSY9 (3)
Format
AP Conjugated (4)
APC (1)
APC Conjugated (5)
Azide-free (8)
Biotin Conjugated (8)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (7)
HRP Conjugated (8)
PE Conjugated (5)
Ready-to-Use (4)
Unconjugated (63)
Epitope
aa36-313 (8)
C-Terminus (4)
aa111-211 (3)
aa1-313 (1)
aa122-313 (1)
aa263-313 (1)
aa265-294 (1)
Publications
No (102)
Showing 1-25 of 102 results

TS / Thymidylate Synthase Antibody (clone 2B2) IHC-plus™ LS-B6165
Mouse Monoclonal [clone 2B2] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA IHC IHC-P IP WB
Unconjugated
50µg  $495.00
Anti-TYMS antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-TYMS antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

TS / Thymidylate Synthase Antibody (clone 2C3) LS-C175670
Mouse Monoclonal [clone 2C3] (IgG2a) to Human TS / Thymidylate Synthase
Human
IHC IHC-P WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TYMS mouse monoclonal antibody.
IHC of paraffin-embedded Human tonsil using anti-TYMS mouse monoclonal antibody.

TS / Thymidylate Synthase Antibody IHC-plus™ LS-B1460
Sheep Polyclonal to Human TS / Thymidylate Synthase
Human
ELISA IF IHC IHC-P IP WB
Unconjugated
50µl 10mg/ml  $425.00
Anti-TYMS antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-Thymidylate Synthase Antibody - Western Blot. Anti-TS is shown to detect thymidylate synthase present in a HeLa cell extract. Each lane is estimated to contain 4 ug of protein. Lanes 1, 2 and 3 represent 1:2000, 1:5000 and 1:10000 fold dilutions of the antibody. Detection was made using HRP Rabbit-a-Sheep IgG (LS-C61113) diluted 1:1000 and color development using TMB (TMBM-100) substrate for approximately 4.

TS / Thymidylate Synthase Antibody LS-C39650
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA IHC IHC-P WB
Unconjugated
100µg  $635.00

TS / Thymidylate Synthase Antibody (clone 10F12) IHC-plus™ LS-B14524
Mouse Monoclonal [clone 10F12] (IgG2a) to Human TS / Thymidylate Synthase
Human
IHC IHC-P WB
Unconjugated
100µl  $425.00
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TYMS (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TYMS.

TS / Thymidylate Synthase Antibody (aa263-313) LS-C290647
Rabbit Polyclonal (IgG) to Human TS / Thymidylate Synthase
Mouse, Human
IHC IP WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human and Mouse TS by Western Blot. Samples: Whole cell lysate (50 ug) from Jurkat, 293T, HeLa, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-TS antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

TS / Thymidylate Synthase Antibody (aa265-294) LS-C203764
Rabbit Polyclonal to Human TS / Thymidylate Synthase
Human
Flo IF IHC IHC-P WB
Unconjugated
400µl  $325.00
TYSY Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
TYSY Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human breast carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

TS / Thymidylate Synthase Antibody LS-C39646
Mouse Monoclonal (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IHC IP WB
Unconjugated
500µl  $665.00

TS / Thymidylate Synthase Antibody LS-C39648
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IHC IHC-Fr IHC-P IP WB
Unconjugated
100µg  $635.00

TS / Thymidylate Synthase Antibody (HRP) LS-C549828
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IHC IP WB
HRP Conjugated
100µl  $800.00

TS / Thymidylate Synthase Antibody (Biotin) LS-C529741
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IHC IP WB
Biotin Conjugated
100µl  $800.00

TS / Thymidylate Synthase Antibody (FITC) LS-C539658
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IHC IP WB
FITC Conjugated
100µl  $800.00

TS / Thymidylate Synthase Antibody (PE) LS-C657802
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IHC IP WB
PE Conjugated
100µl  $800.00

TS / Thymidylate Synthase Antibody (APC) LS-C519522
Mouse Monoclonal (IgG1) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IHC IP WB
APC Conjugated
100µl  $800.00

TS / Thymidylate Synthase Antibody (clone TMS715) LS-C358056
Mouse Monoclonal [clone TMS715] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IHC IHC-P IP WB
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00

TS / Thymidylate Synthase Antibody (clone TMS715, Ready-to-Use) LS-C389724
Mouse Monoclonal [clone TMS715] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IHC IHC-P IP WB
Unconjugated, Ready-to-Use
7ml  $465.00
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TMS715). This image was taken for the unmodified form of this product. Other forms have not been tested.

TS / Thymidylate Synthase Antibody (clone TMS715, Azide-free) LS-C389731
Mouse Monoclonal [clone TMS715] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IHC IHC-P IP WB
Unconjugated, Azide-free
100µg 1mg/ml  $465.00
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TMS715). This image was taken for the unmodified form of this product. Other forms have not been tested.

TS / Thymidylate Synthase Antibody LS-C113044
Mouse Monoclonal to Human TS / Thymidylate Synthase
Human
ELISA Flo ICC IF WB
Unconjugated
50µl 1mg/ml  $315.00; 100µl 1mg/ml  $345.00

TS / Thymidylate Synthase Antibody (clone TS 106) LS-C88210
Mouse Monoclonal [clone TS 106] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IP WB
Unconjugated
0.1ml  $280.00; 0.5ml  $555.00; 1ml  $880.00

TS / Thymidylate Synthase Antibody (clone TS 106, Azide-free) LS-C88211
Mouse Monoclonal [clone TS 106] (IgG1,k) to Human TS / Thymidylate Synthase
Human
ELISA Flo IF IP WB
Unconjugated, Azide-free
0.1ml  $620.00; 0.2ml  $945.00

TS / Thymidylate Synthase Antibody LS-C330762
Rabbit Polyclonal (IgG) to Human TS / Thymidylate Synthase
Human
Flo IF IHC WB
Unconjugated
100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of various cell lines, using TYMS antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.

TS / Thymidylate Synthase Antibody (clone TS106) LS-C391644
Mouse Monoclonal [clone TS106] (IgG1,k) to Human TS / Thymidylate Synthase
Human
Flo IF IHC IHC-P
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TS106).  This image was taken for the unmodified form of this product. Other forms have not been tested.

TS / Thymidylate Synthase Antibody (clone TS106, Azide-free) LS-C391646
Mouse Monoclonal [clone TS106] (IgG1,k) to Human TS / Thymidylate Synthase
Human
Flo IF IHC IHC-P
Unconjugated, Azide-free
100µg 1mg/ml  $465.00
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TS106).  This image was taken for the unmodified form of this product. Other forms have not been tested.

TS / Thymidylate Synthase Antibody (clone TS106, Ready-to-Use) LS-C391648
Mouse Monoclonal [clone TS106] (IgG1,k) to Human TS / Thymidylate Synthase
Human
Flo IF IHC IHC-P
Unconjugated, Ready-to-Use
7ml  $465.00
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TS106).  This image was taken for the unmodified form of this product. Other forms have not been tested.

TS / Thymidylate Synthase Antibody (clone TS106 + TMS715) LS-C391651
Mouse Monoclonal [clone TS106 + TMS715] (IgG1) to Human TS / Thymidylate Synthase
Human
Flo IF IHC IHC-P
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with Thymidylate Synthase antibody (TS106 + TMS715).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Showing 1-25 of 102 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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