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Anti-TS / Thymidylate Synthase Antibody IHC-plus™ LS-B1460

Note: This antibody replaces LS-C19029

Ordering

Wt. Vol. Conc. Price
- 50 µl 10 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular TS / Thymidylate Synthase Antibodies

Anti-TS / Thymidylate Synthase Antibody (clone 2B2) IHC-plus™ LS-B6165
Mouse Monoclonal [clone 2B2] (IgG1,k) to Human TS / Thymidylate Synthase
Human
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated
Immunohistochemistry Image
Anti-TS / Thymidylate Synthase Antibody (clone 10F12) LS-C175645
Mouse Monoclonal [clone 10F12] (IgG2a) to Human TS / Thymidylate Synthase
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-TS / Thymidylate Synthase Antibody (aa263-313) LS-C290647
Rabbit Polyclonal to Human TS / Thymidylate Synthase
Human, Mouse, Rat, Bovine, Dog, Pig, Rabbit
Western blot, Immunoprecipitation
Unconjugated
Western blot Image

100% Guaranteed 100% Guaranteed
Sheep Polyclonal to Human TS / Thymidylate Synthase
Human
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation, ELISA
Unconjugated

Details

Human TS / Thymidylate Synthase
Sheep
Human (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Purified IgG
Unmodified

Applications

  • IHC - Paraffin (5 µg/ml)
  • Immunofluorescence
  • Western blot
  • Immunoprecipitation
  • ELISA

Specificity and Use

TS / Thymidylate Synthase antibody was raised against recombinant human TYMS.
Recombinant human Thymidylate Synthase (36 kD) produced in E. coli.
Immunohistochemistry: LS-B1460 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B1460 was determined to be 5 ug/ml.

Packaging

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About TS / Thymidylate Synthase

P04818 NM_001071 NP_001062.1

TYMS Antibody, HST422 Antibody, Thymidylate synthetase Antibody, TMS Antibody, TS Antibody, Thymidylate synthase Antibody, Tsase Antibody

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

Immunohistochemistry

Immunohistochemistry
Anti-TYMS antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1460 concentration 5 ug/ml.

Western blot

Western blot
Anti-Thymidylate Synthase Antibody - Western Blot. Anti-TS is shown to detect thymidylate synthase present in a HeLa cell extract. Each lane is estimated to contain 4 ug of protein. Lanes 1, 2 and 3 represent 1:2000, 1:5000 and 1:10000 fold dilutions of the antibody. Detection was made using HRP Rabbit-a-Sheep IgG (LS-C61113) diluted 1:1000 and color development using TMB (TMBM-100) substrate for approximately 4.

Requested From: United States
Date Requested: 12/6/2016

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