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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TPP1 / CLN2 Antibody (aa201‑215) LS‑C102868
CLN2 antibody LS-C102868 is an unconjugated goat polyclonal antibody to CLN2 (TPP1) from human and monkey. Validated for Peptide-ELISA and WB.
Catalog
Size
Price
LS-C102868-100
100 µg
Unavailable

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Product Description

CLN2 antibody LS-C102868 is an unconjugated goat polyclonal antibody to CLN2 (TPP1) from human and monkey. Validated for Peptide-ELISA and WB.
About TPP1 / CLN2
TPP1 / CLN2 is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. O14773 NM_000391 NP_000382.3

TPP1 Antibody, CLN2 Antibody, GIG1 Antibody, LPIC Antibody, LINCL Antibody, TPP-I Antibody, Tripeptidyl aminopeptidase Antibody, Tripeptidyl peptidase I Antibody, Tripeptidyl-peptidase 1 Antibody, Tripeptidyl-peptidase I Antibody, TPP-1 Antibody, Growth-inhibiting protein 1 Antibody


Specifications

Target
Human TPP1 / CLN2
Host
Goat
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Predicted
Bovine (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (0.3 - 1 µg/ml)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:4000)
Immunogen
TPP1 / CLN2 antibody was raised against synthetic peptide C-TPSVIRKRYNLTSQD from an internal region of human TPP1 (NP_000382.3). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey (100%); Bovine (93%); Marmoset, Dog, Horse, Rabbit, Opossum (87%); Elephant, Panda, Bat (80%).
Blocking Peptide
LS-E27147 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C102868. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa201-215
Specificity
Human TPP1.
Usage
Peptide ELISA: antibody detection limit dilution 1:4000. Western blot: Approx 65 kDa band observed in Human Placenta lysates (calculated MW of 61.2 kDa according to NP_000382.3). Recommended concentration: 0.3-1 ug/ml.
Presentation
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

TPP1 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein/ml in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
TPP1 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein/ml in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.

Western blot

TPP1 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein/ml in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
TPP1 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein/ml in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.

Western blot

TPP1 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein/ml in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
TPP1 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein/ml in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.

Western blot

TPP1 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein/ml in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
TPP1 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein/ml in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.


Requested From: 
Date Requested: 6/21/2018

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