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TPP1 / CLN2

tripeptidyl peptidase I

TPP1 / CLN2 is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome.

Gene Name: tripeptidyl peptidase I
Family/Subfamily: Protease , Serine S53
Synonyms: TPP1, CLN2, GIG1, LPIC, LINCL, TPP-I, Tripeptidyl aminopeptidase, Tripeptidyl peptidase I, Tripeptidyl-peptidase 1, Tripeptidyl-peptidase I, TPP-1, Growth-inhibiting protein 1
Target Sequences: NM_000391 NP_000382.3 O14773

☰ Filters
Products
Antibodies (39)
Primary (39)
TPP1 / CLN2 (39)
Human (31)
Mouse (14)
Rat (3)
Monkey (1)
IHC (9)
IHC-P (5)
WB (35)
ELISA (9)
ICC (1)
IF (1)
IP (1)
Peptide-ELISA (2)
rabbit (38)
goat (1)
Product Group
IHCPlus (1)
IgG (18)
polyclonal pc (39)
APC (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (4)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (3)
Unconjugated (17)
aa1-320 (8)
aa198-562 (8)
aa6-34 (7)
aa150-200 (1)
aa201-215 (1)
aa224-563 (1)
aa227-261 (1)
aa66-324 (1)
No (39)
TPP1 / CLN2 Antibody - Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa66-324) Antibody
Mouse, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$485
TPP1 / CLN2 Antibody - Western blot analysis of extracts of various cell lines.
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TPP1 / CLN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TPP1 / CLN2 Antibody - Western blot of TPP1 / CLN2 antibody.
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TPP1 / CLN2 Rabbit anti-Mouse Polyclonal (aa198-562) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
TPP1 / CLN2 Antibody - Western blot of TPP1 / CLN2 antibody.
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TPP1 / CLN2 Rabbit anti-Mouse Polyclonal (aa198-562) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
TPP1 / CLN2 Antibody - Western blot of TPP1 / CLN2 antibody.
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TPP1 / CLN2 Rabbit anti-Mouse Polyclonal (aa198-562) (APC, Cy7) Antibody
Mouse
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
TPP1 / CLN2 Antibody - Western blot of TPP1 / CLN2 antibody.
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TPP1 / CLN2 Rabbit anti-Mouse Polyclonal (aa198-562) (Cy3) Antibody
Mouse
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
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TPP1 / CLN2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
TPP1 / CLN2 Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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TPP1 / CLN2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
TPP1 / CLN2 Antibody - TPP1 was detected in paraffin-embedded sections of human lung cancer tissues using rabbit anti- TPP1 Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.
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TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa227-261) Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
TPP1 / CLN2 Antibody - TPP1 antibody detects TPP1 protein at cytosol on normal liver by immunohistochemical analysis. Sample: Paraffin-embedded normal liver. TPP1 antibody dilution:1:500.
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TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa224-563) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
TPP1 / CLN2 Antibody
Select
TPP1 / CLN2 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
TPP1 / CLN2 Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TPP1 / CLN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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TPP1 / CLN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
Select
TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa6-34) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa6-34) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa6-34) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa6-34) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa6-34) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa6-34) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
TPP1 / CLN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Select
TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa150-200) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
TPP1 / CLN2 Antibody - TPP1 antibody (0.3 ug/ml) staining of Human Placenta lysate (35 ug protein/ml in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.
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TPP1 / CLN2 Goat anti-Human Polyclonal (aa201-215) Antibody
Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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TPP1 / CLN2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TPP1 / CLN2 Antibody - TPP1 Antibody western blot of CEM cell line lysates (35 ug/lane). The TPP1 antibody detected the TPP1 protein (arrow).
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TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa6-34) Antibody
Human
WB
Unconjugated
400 µl/$393
TPP1 / CLN2 Antibody - Western blot of TPP1 / CLN2 antibody.
Select
TPP1 / CLN2 Rabbit anti-Human Polyclonal (aa1-320) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).