Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Protein A purified
ELISA (1 - 5 µg/ml)
Specificity and Use
TNFRSF1A / TNFR1 antibody was raised against purified recombinant human soluble TNF Receptor I.
Recognizes natural and recombinant human soluble TNF Receptor I.
Suitable for use in ELISA and Immunoprecipitation. ELISA: (as a capture antibody): 1-5 ug/ml. Coat each well of a microtiter plate with 100 ug of diluted antibody. The recommended buffer is an aqueous solution containing 8g NaCl, 1.42g Na2HPO4-H2O, 0.2g KH2PO4, 0.2g KCl per liter, pH 7.4.
TNFRSF1A / TNFR1 is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.