Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone H398] (IgG2a) to Human TNFRSF1A / TNFR1
Western blot, Immunoprecipitation, Flow Cytometry
Mouse Monoclonal (IgG1) to Human TNFRSF1A / TNFR1
Human TNFRSF1A / TNFR1
Human (tested or 100% immunogen sequence identity)
Protein A purified
ELISA (1 - 5 µg/ml)
Specificity and Use
Purified recombinant human soluble TNF Receptor I.
Recognizes natural and recombinant human soluble TNF Receptor I.
Suitable for use in ELISA and Immunoprecipitation. ELISA: (as a capture antibody): 1-5 ug/ml. Coat each well of a microtiter plate with 100 ug of diluted antibody. The recommended buffer is an aqueous solution containing 8g NaCl, 1.42g Na2HPO4-H2O, 0.2g KH2PO4, 0.2g KCl per liter, pH 7.4.
TNFRSF1A / TNFR1 is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.