Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 9G8] (IgG2b) to Human TNFRSF18 / GITR
IHC, IHC - Paraffin, Western blot
Rat Monoclonal [clone YGITR765.4.16] (IgG2b) to Mouse TNFRSF18 / GITR
Mouse TNFRSF18 / GITR
Mouse (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [YGITR765.4.16]
Specificity and Use
GITR antibody (clone YGITR 765.4.16) detects mouse GITR (also called TNFRSF18), a 228 aa cysteine-rich protein with a molecular weight of approximately 25 kD. GITR is a type I transmembrane protein belonging to the tumor necrosis factor/nerve growth fact.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
TNFRSF18 / GITR is a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death.