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TNFRSF18 / GITR is a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
|Gene Name:||tumor necrosis factor receptor superfamily, member 18|
|Family/Subfamily:||TNF Receptor , not assigned-TNF Receptor|
|Synonyms:||TNFRSF18, AITR, CD357, CD357 antigen, GITR, GITR-D|
|Target Sequences:||NM_004195 NP_004186.1 Q9Y5U5|
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