Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
IHC - Paraffin, Western blot, Flow Cytometry
Human TNFRSF10B / Killer / DR5
Human (tested or 100% immunogen sequence identity)
Protein G purified
IHC - Paraffin
Western blot (5 µg/ml)
Specificity and Use
TNFRSF10B / Killer / DR5 antibody was raised against a peptide corresponding to amino acids 388 to 407 (isoform 2) of human DR5 precursor (1,2). The same sequence is found in isoform 1 at amino acids 417-436.
Human TNFRSF10B / DR5.
Flow: Cell Surface. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Store at -20°C. Aliquot to avoid freeze/thaw cycles.
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently.