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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
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TNFRSF10B / Killer / DR5

tumor necrosis factor receptor superfamily, member 10b

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.

Gene Name: tumor necrosis factor receptor superfamily, member 10b
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: TNFRSF10B, Cytotoxic TRAIL receptor-2, CD262 antigen, DR5, Death receptor 5, KILLER, TRAIL-R2, TRICK2B, TRAILR2, TRICK2A, TRICKB, TRICK2, CD262, Fas-like protein, TRAIL receptor 2, ZTNFR9
Target Sequences: NM_147187 Q6FH58 O14763

Viewing 1-25 of 133 items
TNFRSF10B / Killer / DR5 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone HS201] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flo, Func, ICC, IHC, IHC-P, IP
Unconjugated
50µg   1mg/ml   $425.00
TNFRSF10B / Killer / DR5 Antibody - Anti-DR5 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
Flo, ICC, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
TNFRSF10B / Killer / DR5 Antibody - Anti-DR5 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
TNFRSF10B / Killer / DR5 Antibody - Anti-DR5 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $425.00
TNFRSF10B / Killer / DR5 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone HS201] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flo, Func, ICC, IHC, IHC-P, IP
Unconjugated
50µg   1mg/ml   $425.00
TNFRSF10B / Killer / DR5 Antibody - Anti-Killer / DR5 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
Select
Rabbit Polyclonal to Mouse TNFRSF10B / Killer / DR5
Human
Flo, IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $425.00
TNFRSF10B / Killer / DR5 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TNFRSF10B mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI1B9] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
TNFRSF10B / Killer / DR5 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TNFRSF10B mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Select
Mouse Monoclonal [clone OTI1B9] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
TNFRSF10B / Killer / DR5 Antibody - Human peripheral blood lymphocytes stained with purified DJR2-2, followed by biotinylated anti-mouse IgG and Sav-PE
Select
(1) Publication(s)
Mouse Monoclonal [clone DJR2-2 (2-6)] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flo
Unconjugated
100µg   0.5mg/ml   $275.00
TNFRSF10B / Killer / DR5 Antibody
Select
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $275.00
TNFRSF10B / Killer / DR5 Antibody - Human peripheral blood lymphocytes stained with purified DJR2-4, followed by biotinylated anti-mouse IgG and Sav-PE
Select
(1) Publication(s)
Mouse Monoclonal [clone DJR2-4 (7-8)] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flo
Unconjugated
100µg   0.5mg/ml   $275.00
TNFRSF10B / Killer / DR5 Antibody - Immunohistochemistry detection of endogenous TRAIL-R2 in paraffin-embedded human carcinoma tissues (colon, tonsil) using mAb to TRAIL-R2 (TR2.21) .
Select
Mouse Monoclonal [clone TR2.21] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flo, IHC, IHC-P
Unconjugated
100µg   $415.00
TNFRSF10B / Killer / DR5 Antibody - Immunocytochemistry of HeLa cells fixed by Paraformaldehyde and using DR5 mouse monoclonal antibody diluted 1:100.
Select
Mouse Monoclonal to Human TNFRSF10B / Killer / DR5
Mouse, Human
ICC, WB
Unconjugated
100µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human TNFRSF10B / Killer / DR5
Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $275.00
Select
Mouse Monoclonal [clone DJR2-2 (a.k.a. 2-6)] (IgG1,k) to Human TNFRSF10B / Killer / DR5
Human
Flo
Unconjugated
25µg   0.5mg/ml   $235.00; 100µg   $305.00
TNFRSF10B / Killer / DR5 Antibody - Western blot of Killer / DR5 antibody.
Select
Rabbit Polyclonal to Mouse TNFRSF10B / Killer / DR5
Mouse, Human
WB
Unconjugated
30µg   $245.00; 100µg   500µl   $385.00
TNFRSF10B / Killer / DR5 Antibody - Surface staining of CD262 on CD262-transfectants with the antibody to CD262 (DR5-01-1) PE.
Select
Mouse Monoclonal [clone DR5-01-1] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flo
PE Conjugated
0.1mg   0.1mg/ml   $385.00
TNFRSF10B / Killer / DR5 Antibody - IHC of Killer / DR5 antibody. Human spleen.
Select
Goat Polyclonal to Human TNFRSF10B / Killer / DR5
Human
ELISA, Flo, IHC, WB
Unconjugated
200µg   $475.00
Select
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
Human
Flo, IHC, IHC-P, WB
Unconjugated, Azide-free
100µg   $335.00
TNFRSF10B / Killer / DR5 Antibody - DR5 was detected in paraffin-embedded sections of mouse intestine tissues using rabbit anti- DR5 Antigen Affinity purified polyclonal antibody
Select
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
Human
IHC, IHC-P, WB
Unconjugated
100µg   $355.00
TNFRSF10B / Killer / DR5 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-TNFRSF10B mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI4B12] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
IHC, WB
Unconjugated
100µl   1mg/ml   $345.00
TNFRSF10B / Killer / DR5 Antibody - Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-TNFRSF10B mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI2A5] (IgG1) to Human TNFRSF10B / Killer / DR5
Mouse, Human, Monkey
IHC, WB
Unconjugated
100µl   1mg/ml   $345.00
TNFRSF10B / Killer / DR5 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-TNFRSF10B mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI2A5] (IgG1) to Human TNFRSF10B / Killer / DR5
Mouse, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Mouse Monoclonal [clone HS201] (IgG1) to Human TNFRSF10B / Killer / DR5
Human
Flo, Func, ICC, IP
Biotin Conjugated
100µg   $445.00
TNFRSF10B / Killer / DR5 Antibody - Western blot of recombinant TNFRSF10B / Killer / DR5.
Select
Rabbit Polyclonal to Human TNFRSF10B / Killer / DR5
Human
ICC, IP, WB
Unconjugated
20µl   0.5mg/ml   $195.00; 100µl   0.5mg/ml   $245.00; 200µl   0.5mg/ml   $285.00; 1ml   0.5mg/ml   $475.00

Viewing 1-25 of 133 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).