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Human TMEM142A / ORAI1 | |
Goat | |
Human, Dog, Pig, Rabbit (tested or 100% immunogen sequence identity) | |
Monkey, Bat, Bovine, Horse (at least 90% immunogen sequence identity) | |
Polyclonal | |
Unconjugated | |
Immunoaffinity purified | |
Unmodified |
Synthetic peptide C-KKQPGQPRPTSKP from an internal region of human ORAI1 (NP_116179.2). Percent identity by BLAST analysis: Human, Gorilla, Monkey, Panda, Dog, Rabbit, Pig (100%); Marmoset, Bovine, Bat, Horse (92%); Elephant (85%). | ||
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aa203-215 | ||
Human ORAI1. | ||
Peptide ELISA: antibody detection limit dilution 1:64000. Western Blot: Approx. 50-55kD band observed in Human Liver and Human Placenta lysates (calculated MW of 32.7kD according to NP_116179.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Li et al,, J Biol Chem. 2007 Oct 5;282(40):29448-56.; PMID: 17702753). Recommended concentration: 0.03-0.1 ug/ml. |
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide | |
Store at -20°C. Avoid freeze-thaw cycles. | |
For research use only. |
ORAI1 Antibody, CRACM1 Antibody, ORAT1 Antibody, Protein orai-1 Antibody, TMEM142A Antibody, Transmembrane protein 142A Antibody
Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
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