Ca2+ release-activated Ca2+ (CRAC) channel subunit which mediates Ca2+ influx following depletion of intracellular Ca2+ stores and channel activation by the Ca2+ sensor, STIM1. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.
|Gene Name:||ORAI calcium release-activated calcium modulator 1|
|Synonyms:||ORAI1, CRACM1, ORAT1, Protein orai-1, TMEM142A, Transmembrane protein 142A|
|Target Sequences:||NM_032790 NP_116179.2 Q96D31|
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