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Anti-TLK1 Antibody (C-Terminus) LS-C10636

Ordering

Wt. Vol. Conc. Price
100 µg - - Unavailable

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60 TLK1 Antibodies

Most Popular TLK1 Antibodies

Anti-TLK1 Antibody (C-Terminus) LS-C10636
Rabbit Polyclonal (IgG) to Human TLK1
Human
IHC, Western blot, Immunoprecipitation, ELISA, Functional Assay
Unconjugated
Anti-TLK1 Antibody (aa720-750) LS-C101204
Rabbit Polyclonal to Human TLK1
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-TLK1 Antibody (clone 4B3) LS-C133607
Mouse Monoclonal [clone 4B3] (IgG3,k) to Human TLK1
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-TLK1 Antibody (aa730-779) IHC-plus™ LS-B9860
Rabbit Polyclonal (IgG) to Human TLK1
Human, Mouse
IHC - Paraffin, Immunofluorescence, ELISA
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Immunohistochemistry Image
Anti-TLK1 Antibody LS-C410446
Rabbit Polyclonal (IgG) to Human TLK1
Human
IHC, Western blot
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100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human TLK1
Human
IHC, Western blot, Immunoprecipitation, ELISA, Functional Assay (applications tested for the base form of this product only)
Unconjugated

Details

Human TLK1
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, MaxLight 405, MaxLight 490, MaxLight 550, MaxLight 650, MaxLight 750, PE.
Immunoaffinity purified
Unmodified

Applications

  • IHC (2 µg/ml)
  • Western blot (1 - 2 µg/ml)
  • Immunoprecipitation
  • ELISA (0.1 - 1 µg/ml)
  • Functional Assay
  • (applications tested for the base form of this product only)

Specificity and Use

TLK1 antibody was raised against a synthetic peptide derived from a sequence located near the C-terminus of the human Tlk-1 protein.
C-Terminus
Specific for the ~85kD Tlk1 (Tousled-like kinase 1) protein. It does not cross-react with the related Tlk2 protein. Antibody specificity was confirmed by Western blot with epitope-tagged Tlk1 and Tlk2 proteins, Western blot and immunoprecipitation with HeLa cell lysates and by immunoprecipitation with in vitro transcribed and translated Tlk1 and Tlk2. A nuclear localization of this protein is observed by immunohistochemistry with HeLa cells. Species cross-reactivity: human.
Suitable for use in ELISA, Western Blot, Immunoprecipitation, Immunohistochemistry. ELISA: 0.1-1.0 ug/ml. Immunohistochemistry: 2 ug/ml. Immunoprecipitation: 5 ug/IP reaction. (native and IP-kinase assay). Western Blot: 1-2 ug/ml.

Packaging

PBS, pH 7.4, 05% sodium azide.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
For research use only.

About TLK1

Q9UKI8 NM_012290 NP_036422.3

TLK1 Antibody, KIAA0137 Antibody, Tousled-like kinase 1 Antibody, Snare kinase snak Antibody, PKU-beta Antibody, SNARE protein kinase SNAK Antibody

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs.

Requested From: 
Date Requested: 4/25/2017

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