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Anti-TJP2 / ZO2 / ZO-2 Antibody (C-Terminus) IHC-plus™ LS-B2185

Note: This antibody replaces LS-C26439


Wt. Vol. Conc. Price
50 µg - 0.25 mg/ml Unavailable

Most Popular TJP2 / ZO2 / ZO-2 Antibodies

Anti-TJP2 / ZO2 / ZO-2 Antibody (C-Terminus) IHC-plus™ LS-B2185
Rabbit Polyclonal to Human TJP2 / ZO2 / ZO-2
Human, Mouse, Rat, Dog
IHC - Paraffin, Immunofluorescence, Western blot
Immunohistochemistry Image
Anti-TJP2 / ZO2 / ZO-2 Antibody (aa1171-1190) LS-C313092
Rabbit Polyclonal (IgG) to Human TJP2 / ZO2 / ZO-2
Human, Monkey
IHC - Paraffin, IHC - Frozen, Western blot
Immunohistochemistry Image
Anti-TJP2 / ZO2 / ZO-2 Antibody (aa1149-1167) LS-C313100
Rabbit Polyclonal (IgG) to Mouse TJP2 / ZO2 / ZO-2
Mouse, Rat
IHC - Paraffin, Western blot
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (1)
Rabbit Polyclonal to Human TJP2 / ZO2 / ZO-2
Human, Mouse, Rat, Dog
IHC - Paraffin, Immunofluorescence, Western blot (applications tested for the base form of this product only)


Human TJP2 / ZO2 / ZO-2
Human, Mouse, Rat, Dog (tested or 100% immunogen sequence identity)
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, MaxLight 405, MaxLight 490, MaxLight 550, MaxLight 650, MaxLight 750, PE.
Immunoaffinity purified


  • IHC - Paraffin (5 - 10 µg/ml)
  • Immunofluorescence (2.5 µg/ml)
  • Western blot (1 - 3 µg/ml)
  • (applications tested for the base form of this product only)

Specificity and Use

TJP2 / ZO2 / ZO-2 antibody was raised against synthetic peptide derived from the C-terminal region of human or canine ZO-2.
Recognizes the ~130-160kD human ZO-2 protein, isoforms A or C. A band of unknown origin lower than 75kD may be observed in certain lysates.
Immunohistochemistry: LS-B2185 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2185 was determined to be 5-10 ug/ml. Immunofluorescence: 2.5 ug/ml. Cells need to be fixed with ice-cold ethanol for 30 minutes on ice prior to assays. Positive control: Western Blot: CaCO2 human colorectal adenocarcinoma, MDCK II canine kidney, KNRK rat kidney, and TMCK-1 mouse kidney cell lysates.


PBS, pH 7.4, 0.09% sodium azide.
Short term: 4º C, Long term: aliquot to avoid repeated freezing and thawing, and store at -20º C.
For research use only.

Publications (1)

Mutations in TJP2 cause progressive cholestatic liver disease. Sambrotta M, Strautnieks S, Papouli E, Rushton P, Clark BE, Parry DA, Logan CV, Newbury LJ, Kamath BM, Ling S, Grammatikopoulos T, Wagner BE, Magee JC, Sokol RJ, Mieli-Vergani G, Smith JD, Johnson CA, McClean P, Simpson MA, Knisely AS, Bull LN, Thompson RJ. Nature genetics. Apr;46:326-8. [Full Text Article] [PubMed:24614073] [PMC:PMC4061468]

About TJP2 / ZO2 / ZO-2

Q9UDY2 NM_004817 NP_004808.2

TJP2 Antibody, C9DUPq21.11 Antibody, DUP9q21.11 Antibody, DFNA51 Antibody, ZO-2 Antibody, Zona occludens 2 Antibody, Zonula occludens protein 2 Antibody, Tight junction protein 2 Antibody, Tight junction protein ZO-2 Antibody, ZO2 Antibody, X104 Antibody, Zona occludens protein 2 Antibody

TJP2 / ZO2 / ZO-2 is a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51.


Anti-TJP2 / ZO-2 antibody IHC of human placenta, intermediate trophoblasts. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2185 concentration 10 ug/ml.

Requested From: 
Date Requested: 3/26/2017

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