LSBio The Immunohistochemistry Antibody Company
Products
  • Antibodies
  • All Antibodies
  • Primary Antibodies
  • Secondary Antibodies
  • IHC-plus Antibodies
  • Isotype Control Antibodies
  • ELISA Kits
  • All Kits
  • Sandwich ELISA Kits
  • Competitive EIA Kits
  • Cell-Based ELISA Kits
  • DNA-Binding ELISA Kits
  • Direct ELISA Kits
  • Functional ELISA Kits
  • Phospho-Specific ELISA Kits
  • Custom ELISA Kits
  • Proteins
  • All Proteins
  • Recombinant Proteins
  • Native Proteins
  • Over-expression Lysates
  • Cell and Tissue Lysates
  • Bio-active Proteins
  • Animal-free Proteins
  • Synthetic Peptides
  • Immunohistochemistry
  • Comprehensive IHC Reports
  • Custom IHC Services
  • TCR Screening Services
  • IHC-plus Antibodies
  • Other
  • Blocking Peptides
Services
  • Immunohistochemistry Services

  • Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

  • TCR Screening Services

  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Have a question? CustomerSupport@LSBio.com
Resources
  • Purchasing
  • Product Ordering Terms and Conditions
  • Holiday Schedule
  • About the LSBio Guarantee
  • About Our Rewards Program
  • Reference Material
  • About LSBio (LifeSpan BioSciences Inc.)
  • About Our 2-million Specimen Tissue Bank
  • About Our IHC Validation Process
  • About Our IHC-plus™ Immunohistochemistry Protocol
  • Publications
  • Secure Logins
  • Login to Our Secure FTP Site
  • Login to Our IHC Database
Distributors
Contact Us

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)
How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Quick Order ▾
View Cart

Anti-TDP-43 / TARDBP Antibody LS-C56457

Note: This antibody replaces LS-C56893

Ordering

Wt. Vol. Conc. Price
100 µg - - $325
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular TDP-43 / TARDBP Antibodies

Anti-TDP-43 / TARDBP Antibody (clone 2E2-D3) IHC-plus™ LS-B4521
Mouse Monoclonal [clone 2E2-D3] (IgG1,k) to Human TDP-43 / TARDBP
Human
IHC - Paraffin, Immunofluorescence, Western blot, ELISA, RNA interference
Unconjugated
Immunohistochemistry Image
Anti-TDP-43 / TARDBP Antibody LS-C124633
Rat Monoclonal (IgG2a,k) to Human TDP-43 / TARDBP
Human
IHC, Western blot, ELISA
Unconjugated
Anti-TDP-43 / TARDBP Antibody (C-Terminus) LS-C144920
Rabbit Polyclonal to Mouse TDP-43 / TARDBP
Mouse
IHC, Western blot
Unconjugated

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human TDP-43 / TARDBP
Human, Mouse, Rat
Western blot
Unconjugated

Details

Human TDP-43 / TARDBP
Rabbit
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Affinity purified
Unmodified

Applications

Western blot (0.5 - 1 µg/ml)

Specificity and Use

TDP-43 / TARDBP antibody was raised against an 18 amino acid peptide located near the centre of human TDP43.
Recognizes TAR DNA-binding protein 43 (TDP43), a 43 kD protein that is located in the nucleus. TDP43 is ubiquitously expressed in human tissue, with high levels detected in the lung, pancreas, spleen, placenta and genital tract. AHP1443 recognizes the longer of the two TDP43 isoforms identified. TDP43 is transcriptional repressor protein that binds to chromosomally integrated TAR DNA and represses HIV-1 Transcription. Studies also suggest that TDP43 is involved in the regulation of cystic fibrosis transmembrane conductance regulator (CFTR) splicing, probably through the association with UG repeats at the 3a€™ splice site. A pathologic form of TDP43 has also been identified, which is a major disease protein in ubiquitinated inclusions characteristic of a range of neurodegenerative diseases.
Western Blot: LS-C56457 detects a band of approximately 43kD in L1210 cell lysate.

Packaging

PBS, 0.02% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About TDP-43 / TARDBP

Q13148 NM_007375 NP_031401.1

TARDBP Antibody, ALS10 Antibody, TAR DNA-binding protein-43 Antibody, TDP-43 Antibody, TAR DNA binding protein Antibody, TAR DNA-binding protein 43 Antibody, TDP43 Antibody

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division.

Requested From: United States
Date Requested: 12/6/2016

Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn
Copyright © 2016 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy
Catalog Number