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Catalog Number Size Price
LS-B16438-50 50 µg (0.5 mg/ml) $460 
TDP-43 / TARDBP Antibody - Human SmallIntestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
TDP-43 / TARDBP Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
TDP-43 / TARDBP Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
TDP-43 / TARDBP Antibody - Goat Anti-TARDBP  Antibody (1µg/ml) staining of Human Cerebellum (A), Frontal Cotex (B) and Hippocampus (C) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescencence.
TDP-43 / TARDBP Antibody - Human SmallIntestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
TDP-43 / TARDBP Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
TDP-43 / TARDBP Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
TDP-43 / TARDBP Antibody - Goat Anti-TARDBP  Antibody (1µg/ml) staining of Human Cerebellum (A), Frontal Cotex (B) and Hippocampus (C) lysates (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescencence.
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PathPlus™ Polyclonal Goat anti‑Human TDP‑43 / TARDBP Antibody (aa140‑153, IHC, WB) LS‑B16438

PathPlus™ Polyclonal Goat anti‑Human TDP‑43 / TARDBP Antibody (aa140‑153, IHC, WB) LS‑B16438

Note: This antibody replaces LS-C87393
Antibody:
TDP-43 / TARDBP Goat anti-Human Polyclonal (aa140-153) Antibody
Application:
IHC-P, WB, Peptide-ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$460
LS-B16438-50
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
TDP-43 / TARDBP Goat anti-Human Polyclonal (aa140-153) Antibody
Application:
IHC-P, WB, Peptide-ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
TARDBP (TAR DNA-binding protein 43, TDP-43) is a DNA and RNA-binding transcriptional repressor that regulates transcription and splicing. TARDBP is thought to be involved in microRNA biogenesis, apoptosis and cell division, and it can also repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. It promotes CFTR exon 9 skipping, and the resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TARDBP binds to the mRNA of the neurofilament NEFL in spinal motor neurons, and it may be involved in regulating RNA transport, translation and stability in neurons in hippocampal dendrites. A pathogenic form of TARDBP plays a major role in frontotemporal dementia (FTLD-TDP) and amyotrophic lateral sclerosis (ALS). Furthermore, dysfunctional or upregulated TARDBP is found in Alzheimer’s disease and in cases of chronic traumatic encephalopathy. In immunohistochemistry, TARDBP has high nuclear positivity in all tissues. References: Journal of Neurochemistry. 105 (3): 797–806, PMID: 18088371; Molecular and Cellular Neurosciences. 35 (2): 320–7, PMID 17481916; Molecular and Cellular Neurosciences. 35 (2): 320–7, PMID: 17481916; Transmission. 2018. 125 (4): 591–613, PMID: 29417336; Journal of Neuropathology and Experimental Neurology. 70 (9): 788–98, PMID: 21865887.
Target
Human TDP-43 / TARDBP
Synonyms
TARDBP | ALS10 | TAR DNA-binding protein-43 | TDP-43 | TAR DNA binding protein | TAR DNA-binding protein 43 | TDP43
Host
Goat
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Dog, Pig, Cow (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Modifications
Unmodified
Immunogen
Peptide with sequence C-HISNAEPKHNSNRQ, from the internal region of the protein sequence according to NP_031401.1.
Epitope
aa140-153
Specificity
Human TARDBP.
Applications
  • IHC - Paraffin (5 µg/ml)
  • Western blot (0.3 - 1 µg/ml)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:16000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Peptide ELISA: antibody detection limit dilution 1:16000. Western Blot: Approx. 45kD band observed in Human lysates of cell line Jurkat (calculated MW of 44.7kD according to NP_031401.1). Recommended concentration: 0.3-1 ug/ml.
Presentation
TBS, pH 7.3, 0.02% Sodium Azide, 0.5% BSA
Storage
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About TDP-43 / TARDBP
Q13148 NM_007375 NP_031401.1

Validation

TDP-43 / TARDBP Antibody - Human SmallIntestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human SmallIntestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human SmallIntestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

TDP-43 / TARDBP Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

TDP-43 / TARDBP Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ TDP-43 / TARDBP Antibody (aa140-153) for IHC, WB/Western LS-B16438 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 6/14/2021