Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Monoclonal [clone SP216] (IgG) to Human SIGLEC1 / CD169 / Sialoadhesin
IHC - Paraffin
Rat Monoclonal [clone 3D6.112] (IgG2a) to Mouse SIGLEC1 / CD169 / Sialoadhesin
IHC - Frozen, Immunofluorescence, Flow Cytometry
Unconjugated, Low Endotoxin
Mouse SIGLEC1 / CD169 / Sialoadhesin
Mouse (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [3D6.112]
Protein G purified
IHC - Frozen (1:50 - 1:100)
Flow Cytometry (1:100 - 1:1000)
Specificity and Use
Recognizes mouse CD169, a sialic acid binding site of sialoadhesin. CD169 is a macrophage receptor expressed on stromal macrophages in many tissues, particularly found in lymph nodes, bone marrow and spleen.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.