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SIGLEC1 / CD169 / Sialoadhesin
sialic acid binding Ig-like lectin 1, sialoadhesin
Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.
| Gene Name: | sialic acid binding Ig-like lectin 1, sialoadhesin |
| Family/Subfamily: | Immunoglobulin , not assigned-Immunoglobulin |
| Synonyms: | SIGLEC1, CD169, CD169 antigen, SIGLEC-1, Sialoadhesin, SN, DJ1009E24.1 |
| Target Sequences: | NM_023068 NP_075556.1 Q9BZZ2 |
Publications (6)
1
The species-specific structure of microanatomical compartments in the human spleen: strongly sialoadhesin-positive macrophages occur in the perifollicular zone, but not in the marginal zone. Steiniger B, Barth P, Herbst B, Hartnell A, Crocker PR. Immunology. 1997 92:307-16.
[PubMed:9415041]
[PMC:PMC1364073]
2
Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Hartnell A, Steel J, Turley H, Jones M, Jackson DG, Crocker PR. Blood. 2001 97:288-96. (IHC)
[PubMed:11133773]
3
Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury. Leaf IA, Nakagawa S, Johnson BG, Cha JJ, Mittelsteadt K, Guckian KM, Gomez IG, Altemeier WA, Duffield JS. The Journal of clinical investigation. 2017 127:321-334. (Flo; Mouse)
[Full Text Article]
[PubMed:27869651]
[PMC:PMC5199713]
Related Antibodies: LS-C188785.
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Antibodies
(50)
Type
Primary
(50)
Target
SIGLEC1 / CD169 / Sialoadhesin
(50)
Reactivity
Human
(26)
Mouse
(14)
Rat
(8)
Pig
(6)
Rabbit
(1)
Application
IHC
(15)
IHC-Fr
(9)
IHC-P
(3)
WB
(31)
Flo
(24)
ELISA
(7)
Func
(2)
ICC
(1)
IF
(10)
IP
(12)
Peptide-ELISA
(1)
RIA
(1)
Host
rabbit
(21)
mouse
(17)
rat
(9)
sheep
(3)
Product Group
IHCPlus
(1)
Isotype
IgG
(6)
IgG,k
(1)
IgG1
(9)
IgG2a
(15)
IgG2a,k
(1)
Clonality
monoclonal mc
(25)
polyclonal pc
(23)
recombinant monoclonal rmc
(2)
Clone
2A4D1
(1)
3B11/11
(2)
3D6.112
(7)
7-239
(2)
ED3
(1)
HSn 7D2
(1)
HSN1 7D2
(1)
MOMA-1
(3)
Format
APC
(2)
APC Conjugated
(2)
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(5)
Cy3 Conjugated
(2)
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(2)
FITC Conjugated
(9)
HRP Conjugated
(4)
Low Endotoxin
(1)
PE Conjugated
(5)
RPE Conjugated
(1)
Unconjugated
(20)
Epitope
aa1272-1411
(8)
aa34-240
(8)
1321-1370 aa, Internal
(1)
Extracellular Domain
(1)
Publications
No
(47)
Yes
(3)
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Pig Monoclonal (3B11/11) Antibody
Pig
Flo, IHC, IHC-Fr, IP, WB
Unconjugated
0.1 mg/$457
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Human Monoclonal (HSN1 7D2) Antibody
Human
ELISA, Flo, IHC, IHC-Fr, IHC-P, RIA
Unconjugated
100 µg/$649
SIGLEC1 / CD169 / Sialoadhesin Sheep anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$941
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Rat Monoclonal Antibody
Rat
Flo, IHC, IHC-Fr, IHC-P, IP
Unconjugated
100 µg/$582; 250 µg/$832
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Rat Monoclonal (HRP) Antibody
Rat
Flo, IF, IHC, IP
HRP Conjugated
100 µl/$860
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Rat Monoclonal (Biotin) Antibody
Rat
Flo, IF, IHC, IP
Biotin Conjugated
100 µl/$860
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Rat Monoclonal (FITC) Antibody
Rat
Flo, IF, IHC, IP
FITC Conjugated
100 µl/$860
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Rat Monoclonal (PE) Antibody
Rat
Flo, IF, IHC, IP
PE Conjugated
100 µl/$860
SIGLEC1 / CD169 / Sialoadhesin Rabbit anti-Human Polyclonal (aa1272-1411) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
SIGLEC1 / CD169 / Sialoadhesin Rat anti-Mouse Monoclonal (FITC) (MOMA-1) Antibody
Mouse
Flo, IF
FITC Conjugated
0.1 mg/$495
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Human Monoclonal (7-239) Antibody
Human
Flo, Func, IHC-Fr, IP, WB
Unconjugated
0.1 mg/$302
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Human Monoclonal (PE) (7-239) Antibody
Human
Flo, Func, IHC-Fr, IP, WB
PE Conjugated
100 Tests/$365
SIGLEC1 / CD169 / Sialoadhesin Rat anti-Mouse Monoclonal (MOMA-1) Antibody
Mouse
Flo, IF, IHC-Fr
Unconjugated
0.25 mg/$545
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Human Monoclonal (2A4D1) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µg/$459
SIGLEC1 / CD169 / Sialoadhesin Rat anti-Mouse Monoclonal (FITC) (MOMA-1) Antibody
Mouse
Flo
FITC Conjugated
100 µg/$794
SIGLEC1 / CD169 / Sialoadhesin Rat anti-Mouse Monoclonal (FITC) (3D6.112) Antibody
Mouse
Flo
FITC Conjugated
100 µg/$794
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Rat Monoclonal (ED3) Antibody
Rat
Flo, IF, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$395
SIGLEC1 / CD169 / Sialoadhesin Rat anti-Mouse Monoclonal (Low Endotoxin) (3D6.112) Antibody
Mouse
Flo, IF, IHC-Fr
Unconjugated, Low Endotoxin
0.5 mg/$848
SIGLEC1 / CD169 / Sialoadhesin Rat anti-Mouse Monoclonal (3D6.112) Antibody
Mouse
Flo, IF, IHC-Fr
Unconjugated
0.1 mg/$435; 0.2 mg/$545
SIGLEC1 / CD169 / Sialoadhesin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Human Monoclonal (HSn 7D2) Antibody
Human
ELISA, Flo
Unconjugated
0.1 ml/$386
SIGLEC1 / CD169 / Sialoadhesin Sheep anti-Mouse Polyclonal Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$930
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Pig Monoclonal (HRP) Antibody
Pig
IHC, IP, WB
HRP Conjugated
100 µl/$916
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Pig Monoclonal (Biotin) Antibody
Pig
Flo, IHC, IP, WB
Biotin Conjugated
100 µl/$916
SIGLEC1 / CD169 / Sialoadhesin Mouse anti-Pig Monoclonal (PE) Antibody
Pig
Flo, IHC, IP, WB
PE Conjugated
100 µl/$916
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