Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal to Human RYR2 / Ryanodine Receptor 2
Human, Mouse, Rat, Rabbit
IHC - Paraffin, ICC, Immunofluorescence, Western blot
Mouse Monoclonal (IgG1) to Dog RYR2 / Ryanodine Receptor 2
Dog, Rat, Guinea pig, Pig, Rabbit, Chicken
IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry
Dog RYR2 / Ryanodine Receptor 2
Dog, Rat, Guinea pig, Pig, Rabbit, Chicken (tested or 100% immunogen sequence identity)
IHC - Paraffin
Western blot (1:1000)
Specificity and Use
Canine cardiac ryanodine receptor.
Detects ryanodine receptor 2 (RyR 2) and weakly detects RyR 1. Species cross-reactivity: Cross-reacts with Rabbit, Rat, Canine, Guinea pig, Chicken, Fish and Amphibians. Not yet tested in other species.
Suitable for use in Flow Cytometry, Western Blot Immunoprecipitation and Immunohistochemistry (paraffin-embedded sections).
PBS, pH 7.2, 0.05% sodium azide
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca2+ levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis.