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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RPS6KB1 / P70S6K / S6K Antibody (Thr421) LS‑C34443
S6K antibody LS-C34443 is an unconjugated rabbit polyclonal antibody to S6K (RPS6KB1 / P70S6K) from human, mouse and rat. Validated for IHC and WB.
Catalog
Size
Price
LS-C34443-50
50 µg (1 mg/ml)
Unavailable

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Product Description

S6K antibody LS-C34443 is an unconjugated rabbit polyclonal antibody to S6K (RPS6KB1 / P70S6K) from human, mouse and rat. Validated for IHC and WB.
About RPS6KB1 / P70S6K / S6K
Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. P23443 NM_003161 NP_003152.1

RPS6KB1 Antibody, 70 kDa S6 kinase Antibody, p70 S6KA Antibody, p70-alpha Antibody, p70-S6K Antibody, p70 S6 kinase alpha Antibody, p70s6 kinase Antibody, S6K-beta-1 Antibody, STK14A Antibody, p70 ribosomal S6 kinase Antibody, p70 S6 kinase, alpha 1 Antibody, p70 S6 kinase, alpha 2 Antibody, p70 S6K-alpha Antibody, p70-S6K 1 Antibody, p70S6K Antibody, p70S6K1 Antibody, PS6K Antibody, Ribosomal protein S6 kinase I Antibody, S6K Antibody, S6K1 Antibody, p70 ribosomal S6 kinase alpha Antibody, p70(S6K)-alpha Antibody


Specifications

Target
Human RPS6KB1 / P70S6K / S6K
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • Western blot
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide from human RPS6KB1 / S6K.
Epitope
Thr421
Presentation
PBS, 0.02% sodium azide, 50% glycerol.
Storage
Short term: -20°C; Long term: -70°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Immunohistochemistry

Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase(Ab-421) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase(Ab-421) antibody (left) or the same antibody preincubated with blocking peptide (right).

Western blot

Western blot of extracts from 293 cells using p70 S6 Kinase(Ab-421) antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).
Western blot of extracts from 293 cells using p70 S6 Kinase(Ab-421) antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase(Ab-421) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase(Ab-421) antibody (left) or the same antibody preincubated with blocking peptide (right).

Western blot

Western blot of extracts from 293 cells using p70 S6 Kinase(Ab-421) antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).
Western blot of extracts from 293 cells using p70 S6 Kinase(Ab-421) antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase(Ab-421) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase(Ab-421) antibody (left) or the same antibody preincubated with blocking peptide (right).

Western blot

Western blot of extracts from 293 cells using p70 S6 Kinase(Ab-421) antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).
Western blot of extracts from 293 cells using p70 S6 Kinase(Ab-421) antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase(Ab-421) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunohistochemistry of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase(Ab-421) antibody (left) or the same antibody preincubated with blocking peptide (right).

Western blot

Western blot of extracts from 293 cells using p70 S6 Kinase(Ab-421) antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).
Western blot of extracts from 293 cells using p70 S6 Kinase(Ab-421) antibody(Lane 2) and the same antibody preincubated with blocking peptide(Lane1).


Requested From: 
Date Requested: 6/25/2018

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