Products
Services
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

RPS6KB1 / P70S6K / S6K

ribosomal protein S6 kinase, 70kDa, polypeptide 1

Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR.

Gene Name: ribosomal protein S6 kinase, 70kDa, polypeptide 1
Family/Subfamily: Protein Kinase , P70 RSK
Synonyms: RPS6KB1, 70 kDa S6 kinase, p70 S6KA, p70-alpha, p70-S6K, p70 S6 kinase alpha, p70s6 kinase, S6K-beta-1, STK14A, p70 ribosomal S6 kinase, p70 S6 kinase, alpha 1, p70 S6 kinase, alpha 2, p70 S6K-alpha, p70-S6K 1, p70S6K, p70S6K1, PS6K, Ribosomal protein S6 kinase I, S6K, S6K1, p70 ribosomal S6 kinase alpha, p70(S6K)-alpha
Target Sequences: NM_003161 NP_003152.1 P23443

Publications (2)

1
Progressive loss of epidermal growth factor receptor in a subpopulation of breast cancers: implications in target-directed therapeutics. Choong LY, Lim S, Loh MC, Man X, Chen Y, Toy W, Pan M, Chen CS, Poonepalli A, Hande MP, Tan PH, Salto-Tellez M, Wong CY, Shah N, Druker BJ, Lim YP. Molecular cancer therapeutics. 2007 6:2828-42. [PubMed:17989321]
2
RalA functions as an indispensable signal mediator for the nutrient-sensing system. Maehama T, Tanaka M, Nishina H, Murakami M, Kanaho Y, Hanada K. The Journal of biological chemistry. 2008 283:35053-9. (WB) [PubMed:18948269] [PMC:PMC3259907]


☰ Filters
Product Group
No (226)
RPS6KB1 / P70S6K / S6K Antibody - Anti-RPS6KB1 / S6K antibody IHC of human brain, cortex, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Rabbit Polyclonal (IgG) to Human RPS6KB1 / P70S6K / S6K
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
RPS6KB1 / P70S6K / S6K Antibody - Anti-RPS6KB1 / S6K antibody IHC of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 1E12] (IgG2b,k) to Human RPS6KB1 / P70S6K / S6K
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
RPS6KB1 / P70S6K / S6K Antibody - Anti-RPS6KB1 / S6K antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human RPS6KB1 / P70S6K / S6K
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg   $485.00
RPS6KB1 / P70S6K / S6K Antibody - Anti-RPS6KB1 / S6K antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Select
Goat Polyclonal to Human RPS6KB1 / P70S6K / S6K
Xenopus, Chicken, Bovine, Rabbit, Mouse, Goat, Dog, Bat, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
RPS6KB1 / P70S6K / S6K Antibody - Anti-RPS6KB1 / S6K antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Rabbit Polyclonal (IgG) to Human RPS6KB1 / P70S6K / S6K
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
RPS6KB1 / P70S6K / S6K Antibody - Anti-RPS6KB1 / S6K antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Rabbit Polyclonal (IgG) to Human RPS6KB1 / P70S6K / S6K
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
RPS6KB1 / P70S6K / S6K Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human RPS6KB1 / P70S6K / S6K
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl   1mg/ml   $505.00
RPS6KB1 / P70S6K / S6K Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human RPS6KB1 / P70S6K / S6K
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
100µl   1mg/ml   $505.00
RPS6KB1 / P70S6K / S6K Antibody - Western blot of p70 S6 Kinase phosphorylation expression in Insulin treated Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
Select
Rabbit Polyclonal to Human RPS6KB1 / P70S6K / S6K
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50µg   50µl   1mg/ml   $255.00; 100µg   100µl   1mg/ml   $305.00
RPS6KB1 / P70S6K / S6K Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with RPS6KB1 Antibody (T421) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
Rabbit Polyclonal to Human RPS6KB1 / P70S6K / S6K
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Mouse Monoclonal (IgG2a) to Human RPS6KB1 / P70S6K / S6K
Human
ELISA, WB
Unconjugated
100µl   $575.00
RPS6KB1 / P70S6K / S6K Antibody - IHC of paraffin-embedded breast cancer tissues using RPS6KB1 mouse monoclonal antibody with DAB staining.
Select
Mouse Monoclonal [clone 5G9] (IgG1) to Human RPS6KB1 / P70S6K / S6K
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $365.00
RPS6KB1 / P70S6K / S6K Antibody - Immunohistochemical analysis of S6K1 (pS418) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human RPS6KB1 / P70S6K / S6K
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $265.00
Select
Rabbit Polyclonal to Drosophila RPS6KB1 / P70S6K / S6K
Drosophila, Human
WB
Unconjugated
100µl   $575.00
RPS6KB1 / P70S6K / S6K Antibody - Formalin-fixed and paraffin-embedded human breast carcinoma reacted with RPS6KB1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
Rabbit Polyclonal to Human RPS6KB1 / P70S6K / S6K
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal to Human RPS6KB1 / P70S6K / S6K
Mouse, Rat, Human
WB
Unconjugated
100µg   0.5mg/ml   $575.00
RPS6KB1 / P70S6K / S6K Antibody - Immunohistochemical analysis of S6K1 (pT229) staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human RPS6KB1 / P70S6K / S6K
Rabbit, Mouse, Bovine, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30µl   1mg/ml   $215.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $325.00
RPS6KB1 / P70S6K / S6K Antibody - Immunohistochemical analysis of S6K1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human RPS6KB1 / P70S6K / S6K
Rabbit, Mouse, Bovine, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30µl   1mg/ml   $205.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $305.00
RPS6KB1 / P70S6K / S6K Antibody - Immunohistochemical analysis of S6K1 (pT444) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human RPS6KB1 / P70S6K / S6K
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $265.00
RPS6KB1 / P70S6K / S6K Antibody - IHC of paraffin-embedded Human tonsil using anti-RPS6KB1 mouse monoclonal antibody.
Select
Mouse Monoclonal [clone OTI6B2] (IgG1) to Human RPS6KB1 / P70S6K / S6K
Mouse, Dog, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100µl   0.7mg/ml   $345.00
RPS6KB1 / P70S6K / S6K Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using p70 S6 Kinase Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human RPS6KB1 / P70S6K / S6K
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
RPS6KB1 / P70S6K / S6K Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using p70 S6 Kinase (Phospho-Ser424) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human RPS6KB1 / P70S6K / S6K
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
RPS6KB1 / P70S6K / S6K Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using p70 S6 Kinase (Phospho-Thr421) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human RPS6KB1 / P70S6K / S6K
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
RPS6KB1 / P70S6K / S6K Antibody - Immunohistochemical analysis of S6K1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human RPS6KB1 / P70S6K / S6K
Chicken, Bovine, Rabbit, Dog, Pig, Human
IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $245.00
Select
Rabbit Polyclonal (IgG) to Human RPS6KB1 / P70S6K / S6K
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Bovine, Rabbit, Mouse, Goat, Dog, Human, Monkey
IHC, WB
Unconjugated
50µg   $435.00
Viewing 1-25 of 226 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).