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PIK3R2 / p85 Beta Antibody (clone T15) LS‑C43327
P85 Beta antibody LS-C43327 is an unconjugated mouse monoclonal antibody to p85 Beta (PIK3R2) from human, bovine and monkey. Validated for IHC, IP and WB.
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Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Bovine, Human, Monkey
Applications:
IHC, IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation
Species:
Human
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Guinea pig, Pig, Sheep
Applications:
IHC, IHC - Paraffin, Western blot
Product Description
P85 Beta antibody LS-C43327 is an unconjugated mouse monoclonal antibody to p85 Beta (PIK3R2) from human, bovine and monkey. Validated for IHC, IP and WB.
About PIK3R2 / p85 Beta
Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology.
O00459
NM_005027
NP_005018.1
PIK3R2 Antibody, p85 Antibody, p85B Antibody, p85-BETA Antibody, PI3K regulatory subunit beta Antibody, MPPH Antibody, PI3-kinase subunit p85-beta Antibody
Specifications
Target
Bovine PIK3R2 / p85 Beta
Host
Mouse
Reactivity
Bovine, Human, Monkey
(tested or 100% immunogen sequence identity)
Clonality
IgG1
Monoclonal
[T15]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
- IHC
- IHC - Frozen
- Western blot (1:500 - 1:1000)
- Immunoprecipitation (10 µg/ml)
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Immunogen
Balculovirus expressed (Recombinant) Bovine P85 beta subunit of P13 kinase.
Specificity
Recognizes the HLA-B27 alloantigen. Reacts with the peripheral blood lymphocytes of 47/47 individuals conventionally typed as HLA-B27 + and precipitates cell surface molecules of 43 and 12 kD, corresponding to the HLA Class 1 heavy chain and beta 2 microglobulin. Affinity studies by Scatchard analysis showed that this has a higher affinity for HLA-B27 (9.7 x 108 M-1) than for HLA B7 (9.5 x 107 M-1). Subjects Expected Fluorescence Intensity Heterozygous HLA-B27+ Strong Homozygous HLA-B27+ Strong Heterozygous HLA-B7+ Faint Non B27, Non B7 Negative.
Presentation
0.09% sodium azide.
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
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Requested From:
Date Requested: 6/22/2018
Date Requested: 6/22/2018
