Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 158-2B3] (IgG1) to Human PECAM-1 / CD31
Flow Cytometry, Functional Assay
Human PECAM-1 / CD31
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [158-2B3]
Protein A purified
Specificity and Use
PECAM-1 / CD31 antibody was raised against stimulated human leukocytes.
Domain 1 of CD31.
Function: Blocks homophilic interaction and heterophilic transendothelial migration. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
50 mM sodium phosphate, pH 7.5, 100 mM potassium chloride, 150 mM sodium chloride, 5% Glycerol, 0.2% BSA, 0.04% sodium azide
Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes.