Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 3C6] (IgG2a) to Human PDCD1 / CD279 / PD-1
IHC - Paraffin, Flow Cytometry
Hamster Polyclonal (IgG) to Mouse PDCD1 / CD279 / PD-1
Mouse PDCD1 / CD279 / PD-1
Mouse (tested or 100% immunogen sequence identity)
Protein G purified
Flow Cytometry (2 µg/10E6 cells)
Specificity and Use
PD-1 cDNA transfectant.
PD1 monoclonal antibody reacts with mouse PD-1 (programmed death-1), a 55 kD member of the Ig superfamily that has been demonstrated to play a key role in the regulation of immune response and peripheral tolerance. PD1 is expressed on activated T and B l.
PDCD1 / CD279 / PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure.