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PDCD1 / CD279 / PD-1

programmed cell death 1

PDCD1 / CD279 / PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Gene Name: programmed cell death 1
Family/Subfamily: Apoptosis
Synonyms: PDCD1, CD279, HPD-1, HPD-l, PD1, Protein PD-1, SLEB2, PD-1, CD279 antigen, Programmed cell death 1
Target Sequences: NM_005018 NP_005009.2 Q15116

Publications (9)

1
Simian immunodeficiency virus (SIV)-specific CD8+ T-cell responses in vervet African green monkeys chronically infected with SIVagm. Zahn RC, Rett MD, Korioth-Schmitz B, Sun Y, Buzby AP, Goldstein S, Brown CR, Byrum RA, Freeman GJ, Letvin NL, Hirsch VM, Schmitz JE. Journal of virology. 2008 82:11577-88. [PubMed:18829748] [PMC:PMC2583661] Related Antibodies: LS-C40800.
2
Cutting edge: Programmed death-1/programmed death ligand 1 interaction regulates the induction and maintenance of invariant NKT cell anergy. Chang WS, Kim JY, Kim YJ, Kim YS, Lee JM, Azuma M, Yagita H, Kang CY. Journal of immunology (Baltimore, Md. : 1950). 2008 181:6707-10. [PubMed:18981087] Related Antibodies: LS-C40800.
3
Human immunodeficiency virus type 1 escapes from interleukin-2-producing CD4+ T-cell responses without high-frequency fixation of mutations. Jones RB, Yue FY, Gu XX, Hunter DV, Mujib S, Gyenes G, Mason RD, Mohamed R, MacDonald KS, Kovacs C, Ostrowski MA. Journal of virology. 2009 83:8722-32. [PubMed:19553327] [PMC:PMC2738181] Related Antibodies: LS-C40800.
4
Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic. Vojnov L, Reed JS, Weisgrau KL, Rakasz EG, Loffredo JT, Piaskowski SM, Sacha JB, Kolar HL, Wilson NA, Johnson RP, Watkins DI. Journal of virology. 2010 84:753-64. [PubMed:19889785] [PMC:PMC2798340] Related Antibodies: LS-C40800.
5
Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling. Radziewicz H, Ibegbu CC, Hon H, Bdard N, Bruneau J, Workowski KA, Knechtle SJ, Kirk AD, Larsen CP, Shoukry NH, Grakoui A. Journal of immunology (Baltimore, Md. : 1950). 2010 184:2410-22. [PubMed:20100932] [PMC:PMC2924663] Related Antibodies: LS-C40800.
6
Memory CCR6+CD4+ T cells are preferential targets for productive HIV type 1 infection regardless of their expression of integrin 7. Monteiro P, Gosselin A, Wacleche VS, El-Far M, Said EA, Kared H, Grandvaux N, Boulassel MR, Routy JP, Ancuta P. Journal of immunology (Baltimore, Md. : 1950). 2011 186:4618-30. [PubMed:21398606] Related Antibodies: LS-C40800.
7
Dominant clonotypes within HIV-specific T cell responses are programmed death-1high and CD127low and display reduced variant cross-reactivity. Conrad JA, Ramalingam RK, Smith RM, Barnett L, Lorey SL, Wei J, Simons BC, Sadagopal S, Meyer-Olson D, Kalams SA. Journal of immunology (Baltimore, Md. : 1950). 2011 186:6871-85. [PubMed:21562156] [PMC:PMC3403726] Related Antibodies: LS-C40800.
8
Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma. Matias Autio, Suvi-Katri Leivonen, Oscar Brück, Satu Mustjoki, Judit Mészáros Jørgensen, Marja-Liisa Karjalainen-Lindsberg, Klaus Beiske, Harald Holte, Teijo Pellinen, Sirpa Leppä. Haematologica. 2020 February; [Full Text Article] [PubMed:32079690] [PMC:PMC7927991] Related Antibodies: LS-B12784.
9
Somatic Mutations and Immune Alternation in Rectal Cancer Following Neoadjuvant Chemoradiotherapy. Dengbo Ji , Haizhao Yi , Dakui Zhang , Tiancheng Zhan, Zhaowei Li, Ming Li, Jinying Jia, Meng Qiao, Jinhong Xia, Zhiwei Zhai, Can Song, Jin Gu. Cancer immunology research. 2018 Nov;6:1401-1416. [Full Text Article] [PubMed:30282671] Related Antibodies: LS-B540.
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PDCD1 / CD279 / PD-1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (3C6) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
50 µl/$440
PDCD1 / CD279 / PD-1 Antibody - Anti-PD1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PDCD1 / CD279 / PD-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
PDCD1 / CD279 / PD-1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (11B2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
PDCD1 / CD279 / PD-1 Antibody - Anti-PD1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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PDCD1 / CD279 / PD-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
PDCD1 / CD279 / PD-1 Antibody - Anti-CD279 / PD-1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 20 ug/ml.
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PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (J116) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µg/$440
PDCD1 / CD279 / PD-1 Antibody - PHA-stimulated (day-3) human peripheral blood lymphocytes stained with purified EH12.2H7, followed by anti-mouse IgG FITC
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PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (EH12.2H7) Antibody
Human
Flo
Unconjugated
100 µg/$249
PDCD1 / CD279 / PD-1 Antibody - Immunohistochemistry of PD-1 in mouse brain tissue with PD-1 antibody at 2.5 ug/ml.
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PDCD1 / CD279 / PD-1 Mouse anti-Mouse Monoclonal (7A11B1) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$428
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PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (aa21-167) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$579
PDCD1 / CD279 / PD-1 Antibody - Cell lysates of 293T and U937 (40 ug) were resolved by SDS-PAGE, transferred to NC membrane and probed with anti-human PDCD1 (1:500). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
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PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (aa21-167) (4F12) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$293; 100 µl/$355
PDCD1 / CD279 / PD-1 Antibody - PDCD1 / CD279 / PD-1 antibody flow cytometric analysis of paraformaldehyde fixed Jurkat cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
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PDCD1 / CD279 / PD-1 Goat anti-Human Polyclonal (Internal) Antibody
Mouse, Dog, Bovine, Rat, Human
Flo, Peptide-ELISA
Unconjugated
100 µg/$455
PDCD1 / CD279 / PD-1 Antibody - IHC testing of FFPE human tonsil with PD-1 antibody (clone RMPD1-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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PDCD1 / CD279 / PD-1 Rabbit anti-Human Monoclonal (RMPD1-1) Antibody
Human
IHC, IHC-P
Unconjugated
20 µg/$354; 100 µg/$550
PDCD1 / CD279 / PD-1 Antibody - IHC of PD-1 on FFPE Tonsil tissue.
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PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (NAT-105) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$307
PDCD1 / CD279 / PD-1 Antibody - Western blot of recombinant PDCD1 / CD279 / PD-1.
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PDCD1 / CD279 / PD-1 Rabbit anti-Human Polyclonal (aa41-132) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$289; 200 µl/$327; 500 µl/$454; 1 ml/$517
PDCD1 / CD279 / PD-1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (8H7) Antibody
Human
Flo, ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PDCD1 / CD279 / PD-1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (5D3) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P
Unconjugated
0.1 mg/$485
PDCD1 / CD279 / PD-1 Antibody - (A) Immunohistochemistry of PD-1 in human breast cancer tissue with PD-1 [4C7] antibody at 10 ug/mL. (B) Immunohistochemistry in human breast cancer tissue with control mouse IgG staining at 10 ug/mL.
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PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (4C7) Antibody
Human
ELISA, Flo, ICC, IF, IHC-P, WB
Unconjugated
0.1 mg/$464
PDCD1 / CD279 / PD-1 Antibody - IHC of paraffin-embedded Human tonsil using anti-PDCD1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (OTI4F10) Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$409
PDCD1 / CD279 / PD-1 Antibody - Surface staining of PHA-activated (3 days) human PBMC with anti-human CD279 (EH12.2H7) PE.
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PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (PE) (EH12.2H7) Antibody
Human, Non-Human Primates
Flo, Func, IHC-Fr
PE Conjugated
100 Tests/$355
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PDCD1 / CD279 / PD-1 Goat anti-Mouse Polyclonal (Extracellular Domain) Antibody
Mouse
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$819
PDCD1 / CD279 / PD-1 Antibody - Western blot of recombinant PDCD1 / CD279 / PD-1.
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PDCD1 / CD279 / PD-1 Rabbit anti-Rat Polyclonal (aa39-266) Antibody
Rat
WB
Unconjugated
100 µl/$297; 200 µl/$338; 500 µl/$475; 1 ml/$543
PDCD1 / CD279 / PD-1 Antibody - Western blot of recombinant PDCD1 / CD279 / PD-1.
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PDCD1 / CD279 / PD-1 Rabbit anti-Rat Polyclonal (aa39-266) (APC) Antibody
Rat
WB
APC Conjugated
100 µl/$390; 200 µl/$475; 500 µl/$816; 1 ml/$889
PDCD1 / CD279 / PD-1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (2F6) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PDCD1 / CD279 / PD-1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (4E5) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
PDCD1 / CD279 / PD-1 Antibody - Immunohistochemistry of PD-1 in mouse brain tissue with PD-1 antibody at 2.5 ug/ml.
Select
PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (12A7D7) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
0.1 mg/$428
PDCD1 / CD279 / PD-1 Antibody
Select
PDCD1 / CD279 / PD-1 Mouse anti-Human Monoclonal (J110) Antibody
Human
Flo, WB
Unconjugated
100 µg/$426
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).