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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PAPPA / PAPP‑A Antibody LS‑C131553
Antibody
PAPP-A antibody LS-C131553 is an unconjugated mouse monoclonal antibody to human PAPP-A (PAPPA). Validated for ELISA and IP.
Catalog
Size
Price
LS-C131553-1000
1000 µg
Unavailable

Popular PAPPA / PAPP-A Products

Antibody
Species: Human
Applications: ELISA
Antibody
Species: Human
Applications: Immunoprecipitation
Antibody
Species: Human
Applications: Immunoprecipitation
PAPP A Antibody (5H9) -Detection of human PAPP-A and proMBP subunits of htPAPP-A by monoclonal antibodies in Western blotting. Lane 4:5H9 (proMBP-specific)after SDS-PAGE in reduction conditions.
Species: Human
Applications: Western blot, ELISA
PAPP A antibody IHC-paraffin: Human Placenta Tissue.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot

Product Description

PAPP-A antibody LS-C131553 is an unconjugated mouse monoclonal antibody to human PAPP-A (PAPPA). Validated for ELISA and IP.
About PAPPA / PAPP-A
Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. Q13219 NM_002581 NP_002572.2

PAPPA Antibody, DIPLA1 Antibody, IGF-dependent IGFBP-4 protease Antibody, PAPPA1 Antibody, PAPA Antibody, PAPP-A Antibody, Pappalysin-1 Antibody, ASBABP2 Antibody, IGFBP-4ase Antibody


Specifications

Target
Human PAPPA / PAPP-A
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein A purified
Modifications
Unmodified
Applications
  • Immunoprecipitation
  • ELISA
  • (applications tested for the base form of this product only)
Immunogen
PAPPA / PAPP-A antibody was raised against purified human atherosclerotic tissue heterotetrameric form of PAPP-A (PAPP-A/proMBP complex).
Specificity
Recognizes human heterotetrameric PAPP-A (htPAPP-A placental blood form consisting of PAPP-A subunits and pro-MBP subunits) and dimeric PAPP-A (dPAPP-A atherosclerotic tissue form consisting of two PAPP-A subunits).
Usage
Suitable for use in ELISA and Immunoprecipitation.
Presentation
PBS, pH 7.4, 0.1% sodium azide
Storage
May be stored at 4°C for short-term only. For long-term storage and to avoid freeze-thaw cycles, aliquot and store at -20°C. Aliquots are stable for at least 1 year at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/23/2018

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