Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
P2RY1 / P2Y1 antibody was raised against synthetic peptide derived from the intracellular C-terminal region of the human P2Y1 receptor protein.
Reacts with the mouse and rat P2Y1 receptor proteins. On Western blots, a strong clear band ~63kD is exhibited. This molecular weight corresponds to a published report of the P2Y1 receptor; however, other publications have described this protein at 40 and 42kD. Reactivity is confirmed with mouse brain homogenates. Species sequence homology: Human and bovine.
Suitable for use in Western Blot and ELISA. Western Blot: 1-3 ug/ml. ELISA: 1 ug/ml. Positive control: Mouse brain homogenates.
PBS, pH 7.4, 0.05% Sodium Azide
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
P2RY1 / P2Y1 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.