Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ONECUT1 Antibody, Hepatocyte nuclear factor 6 Antibody, HNF6 Antibody, One cut domain family member 1 Antibody, One cut homeobox 1 Antibody, HNF-6 Antibody, HNF6A Antibody
ONECUT1 / HNF6 is a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.
IHC of HNF6 in formalin-fixed, paraffin-embedded human liver tissue using an isotype control (top) and LS-C148720 (bottom) at 5 ug/ml.
Western blot of HNF6 in human pancreas in the 1) absence and 2) presence of immunizing peptide, and 3) rat pancreas using LS-C148720 at 4 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution were used for this test.