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Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter.
Gene Name: | NK2 homeobox 2 |
Synonyms: | NKX2-2, Homeobox protein Nkx-2.2, NK-2 (Drosophila) homolog B, NK2 homeobox 2, NKX2.2, NKX2B, NK-2 homolog B |
Target Sequences: | NP_035049.1 P42586 |
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