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Anti-NBN / Nibrin Antibody (aa337-350) LS-C16844

Ordering

Wt. Vol. Conc. Price
200 µg - - $495
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular NBN / Nibrin Antibodies

Anti-NBN / Nibrin Antibody (clone 1D7) IHC-plus™ LS-B1701
Mouse Monoclonal [clone 1D7] (IgG1) to Human NBN / Nibrin
Human
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image
Anti-NBN / Nibrin Antibody (N-Terminus) LS-C153699
Rabbit Polyclonal to Human NBN / Nibrin
Human
IHC, Western blot
Unconjugated
Immunohistochemistry Image
Anti-NBN / Nibrin Antibody (aa609-638, APC) LS-C223408
Rabbit Polyclonal (IgG) to Human NBN / Nibrin
Human
ICC, Immunofluorescence, Western blot, Flow Cytometry, ELISA
APC Conjugated

100% Guaranteed 100% Guaranteed
Mouse Monoclonal (IgG2a) to Human NBN / Nibrin
Human
Western blot, Immunoprecipitation
Unconjugated

Details

Human NBN / Nibrin
Mouse
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal
Unconjugated
Protein A purified
Unmodified

Applications

  • Western blot
  • Immunoprecipitation

Specificity and Use

NBN / Nibrin antibody was raised against kLH-conjugated, synthetic peptide corresponding to amino acids 337-350 (TPGPSLpSQGVSVDE) of human Nibrin/nbs1.
aa337-350
Recognizes phosphorylated Nibrin/nbs1 (Ser343), Mr ~100kD, which exhibits slower mobility in SDS-PAGE relative to unphosphorylated Nibrin. Species cross-reactivity: Human, not mouse.
Suitable for use in Western Blot, Immunoprecipitation. Immunoprecipitation/. Western Blot Analysis: 1 ug/ml detects phospho-Nibrin/nbs1 (Ser343) in nibrin-containing immune complexes collected with 3 ul anti-Nibrin from RIPA lysates of etoposide-treated (10 ug/ml for 1 hour), but not untreated, Jurkat cells. Nibrin-containing immune complexes, from either untreated or etoposide-treated Jurkat cell lysates, were resolved by electrophoresis, transferred to nitrocellulose and probed with either anti-Nibrin (1 ug/ml) or with anti-phospho-Nibrin/nbs1 (Ser343) (1 ug/ml). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and a chemiluminescence detection system.

Packaging

0.1 M Tris-glycine, pH 7.4, 0.15 M sodium chloride, 0.05% sodium azide, 30% glycerol.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
For research use only.

About NBN / Nibrin

O60934 NM_002485 NP_002476.2

NBN Antibody, ATV Antibody, AT-V2 Antibody, Nibrin Antibody, NBS1 Antibody, AT-V1 Antibody, NBS Antibody, p95 Antibody

Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A.

Requested From: United States
Date Requested: 12/7/2016

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