Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
NALP1 / NLRP1 is a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells.
Formalin-fixed, paraffin-embedded human tissue sections probed with NALP1 antibody at 1:2000. A, bone marrow. B, brain glioma core from a brain cancer microarray. A1 and B1 are higher magnifications of A and B, respectively. Hematoxylin-Eos in counterstain.
Formalin-fixed, paraffin-embedded normal human tissue sections probed using NLRP1 antibody at 1:2000. A, epidermis. B, esophagus. C, uterine cervix. D, thymus. Hematoxylin-Eosin counterstain. In A-C, NLRP1 expression is associated with differentiation in stratified epithelial of the skin, esophagus, and cervix.
Western blot of NLRP1 in adult human tissue lysates using NLRP1 antibody at 1:2000. Full-length NLRP1 protein was detected at highest levels in kidney, brain and epidermis. A smaller band was detected in thymus, possibly representing a NLRP1 breakdown product or alternatively spliced form. 293T/NALP1: positive control, 293T cells transiently transfected with full-length NLRP1.
Requested From: United States
Date Requested: 2/22/2017