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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MLH1 Antibody (aa458‑489) LS‑C158152
MLH1 antibody LS-C158152 is an unconjugated mouse monoclonal antibody to human MLH1. Validated for WB.
Catalog
Size
Price
LS-C158152-100
100 µl
Unavailable

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Product Description

MLH1 antibody LS-C158152 is an unconjugated mouse monoclonal antibody to human MLH1. Validated for WB.
About MLH1
Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. P40692 NM_000249 NP_000240.1

MLH1 Antibody, COCA2 Antibody, FCC2 Antibody, HMLH1 Antibody, HNPCC Antibody, HNPCC2 Antibody, MutL protein homolog 1 Antibody


Specifications

Target
Human MLH1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated
Purification
Ascites
Modifications
Unmodified
Applications
  • Western blot (1:100 - 1:400)
Epitope
aa458-489
Specificity
This MLH1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 458-489 amino acids from the Central region of human MLH1.
Presentation
Ascites, 0.09% sodium azide
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

MLH1 Antibody (Ascites)western blot of A549 cell line lysates (35 ug/lane). The MLH1 antibody detected the MLH1 protein (arrow).
MLH1 Antibody (Ascites)western blot of A549 cell line lysates (35 ug/lane). The MLH1 antibody detected the MLH1 protein (arrow).

Western blot

MLH1 Antibody (Ascites)western blot of A549 cell line lysates (35 ug/lane). The MLH1 antibody detected the MLH1 protein (arrow).
MLH1 Antibody (Ascites)western blot of A549 cell line lysates (35 ug/lane). The MLH1 antibody detected the MLH1 protein (arrow).

Western blot

MLH1 Antibody (Ascites)western blot of A549 cell line lysates (35 ug/lane). The MLH1 antibody detected the MLH1 protein (arrow).
MLH1 Antibody (Ascites)western blot of A549 cell line lysates (35 ug/lane). The MLH1 antibody detected the MLH1 protein (arrow).

Western blot

MLH1 Antibody (Ascites)western blot of A549 cell line lysates (35 ug/lane). The MLH1 antibody detected the MLH1 protein (arrow).
MLH1 Antibody (Ascites)western blot of A549 cell line lysates (35 ug/lane). The MLH1 antibody detected the MLH1 protein (arrow).


Requested From: 
Date Requested: 6/18/2018

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