Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
MIB1 Antibody, DIP-1 Antibody, DIP1 Antibody, Mindbomb homolog 1 Antibody, KIAA1323 Antibody, Mind bomb homolog 1 Antibody, Ubiquitin ligase protein MIB1 Antibody, Ubiquitin ligase mind bomb Antibody, ZZZ6 Antibody, DAPK-interacting protein 1 Antibody, Mib Antibody, ZZANK2 Antibody
E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis By similarity.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Immunofluorescent staining of HeLa cells incubated with MIB Antibody at a dilution of 1:20. Data courtesy of Dr. Vyacheslav Akimov, University of Southern Denmark.
MIB Antibody (K28) western blot of K562 cell line lysates (35 ug/lane). The MIB antibody detected the MIB protein (arrow).
Requested From: United States
Date Requested: 2/22/2017