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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MHC Class II Antibody (clone YKIX334.2, FITC) LS‑C57164
MHC Class II antibody LS-C57164 is an FITC-conjugated rat monoclonal antibody to dog MHC Class II. Validated for Flow.
Catalog
Size
Price
LS-C57164-100
100 tst
Unavailable

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Product Description

MHC Class II antibody LS-C57164 is an FITC-conjugated rat monoclonal antibody to dog MHC Class II. Validated for Flow.
About MHC Class II
MHC (major histocompatibility complex) class II molecules are a family of molecules normally found only on antigen-presenting cells such as dendritic cells, mononuclear phagocytes, some endothelial cells, thymic epithelial cells, and B cells. The antigens presented by class II peptides are derived from extracellular proteins (not cytosolic as in class I); hence, the MHC class II-dependent pathway of antigen presentation is called the endocytic or exogenous pathway.

Specifications

Target
Dog MHC Class II
Host
Rat
Reactivity
Dog (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal [YKIX334.2]
Conjugations
Fluorescein
Purification
Affinity purified
Modifications
Unmodified
Applications
  • Flow Cytometry (1:1)
Immunogen
MHC Class II antibody was raised against con A activated canine peripheral blood cells.
Specificity
Recognizes a monomorphic epitope on canine MHC Class II and was classified at the First Canine Leucocyte Antigen Workshop. The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In dogs, this is referred to as the dog leukocyte antigen (DLA) region. Is an antigen of ~32/34kD and blocks the proliferation of MHC Class II dependent responses in vitro. In dogs, MHC Class II is expressed by all peripheral blood mononuclear cells.
Usage
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Presentation
PBS, 0.09% sodium azide, 1% BSA.
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Flow Cytometry

Staining of canine peripheral blood lymphocytes with rat anti-canine MHC CLASS II: FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of canine peripheral blood lymphocytes with rat anti-canine MHC CLASS II: FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Flow Cytometry

Staining of canine peripheral blood lymphocytes with rat anti-canine MHC CLASS II: FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of canine peripheral blood lymphocytes with rat anti-canine MHC CLASS II: FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Flow Cytometry

Staining of canine peripheral blood lymphocytes with rat anti-canine MHC CLASS II: FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of canine peripheral blood lymphocytes with rat anti-canine MHC CLASS II: FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Flow Cytometry

Staining of canine peripheral blood lymphocytes with rat anti-canine MHC CLASS II: FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Staining of canine peripheral blood lymphocytes with rat anti-canine MHC CLASS II: FITC. This image was taken for the unconjugated form of this product. Other forms have not been tested.


Requested From: 
Date Requested: 6/23/2018

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