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Anti-LYN Antibody (aa8-238, clone LYN-01) LS-C44852

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml Unavailable

Most Popular LYN Antibodies

Anti-LYN Antibody (aa8-238, clone LYN-01) LS-C40941
Mouse Monoclonal [clone LYN-01] (IgG1) to Human LYN
Human, Mouse, Rat
ICC, Western blot, Immunoprecipitation
Unconjugated
Western blot Image
Anti-LYN Antibody (aa32-62) LS-C99383
Rabbit Polyclonal to Human LYN
Human, Mouse
IHC - Paraffin, Western blot, Flow Cytometry
Unconjugated
Immunohistochemistry Image
Anti-LYN Antibody (aa39-58) IHC-plus™ LS-B7849
Mouse Monoclonal (IgG2a,k) to Human LYN
Human, Mouse, Rat
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone LYN-01] (IgG1) to Human LYN
Human, Mouse, Rat
Immunofluorescence, Western blot, Immunoprecipitation
Unconjugated

Details

Human LYN
Mouse
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [LYN-01]
Unconjugated
Protein A purified
Unmodified

Applications

  • Immunofluorescence
  • Western blot (1:100 - 1:1000)
  • Immunoprecipitation

Specificity and Use

LYN antibody was raised against recombinant fragment of human Lyn (amino acids 8-238).
aa8-238
Recognizes p56/p53lyn (lyn), a 56kD member of the src family of non-receptor protein tyrosine kinases (PTKs), predominantly expressed in tissues of hematopoietic origin. The interaction between lyn and syk, is crucial for regulating the response of both mast cells and basophils, following Fc epsilon R1 receptor aggregation and activation. Once activated, the rapid tyrosine phosphorylation of ITAMs by lyn, serves as a binding site for the recruitment and activation of syk, triggering the phosphorylation of further adaptor and signaling molecules further down a complex signaling cascade. This chain of events involving receptor aggregation, activation and tyrosine phosphorylation of ITAMs, is also vital for the survival and differentiation of B cells through the interaction of lyn and syk with the B cell receptor (BCR).
Western Blot: LS-C44852 detects a band of approximately 53-56kD in human peripheral blood monocytes.

Packaging

PBS, pH 7.4, 0.09% sodium azide.
For research use only.

About LYN

P07948 NM_002350 NP_002341.1

LYN Antibody, Lyn protein tyrosine kinase Antibody, Lyn ptk Antibody, Lyn tyrosine kinase Antibody, p56Lyn Antibody, p53Lyn Antibody, Tyrosine-protein kinase Lyn Antibody, JTK8 Antibody, Lyn kinase Antibody

Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context.

Requested From: 
Date Requested: 3/29/2017

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