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LIG1 / DNA Ligase 1 is a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.
Gene Name: | ligase I, DNA, ATP-dependent |
Synonyms: | LIG1, DNA ligase I, DNA ligase 1, Ligase I, DNA, ATP-dependent |
Target Sequences: | NM_000234 NP_000225.1 P18858 |
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