Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal to Human KRT20 / CK20 / Cytokeratin 20
Human, Mouse, Rat
IHC - Paraffin, Immunofluorescence, Western blot
Mouse Monoclonal [clone MKs20-8] (IgG2a) to Human KRT20 / CK20 / Cytokeratin 20
IHC - Paraffin, IHC - Frozen, ICC, Western blot, Immunoprecipitation
Human KRT20 / CK20 / Cytokeratin 20
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [MKs20-8]
IHC - Paraffin (1:50)
IHC - Frozen
Specificity and Use
Electrophoretically purified keratin K20 from human intestinal mucosa
Keratin 20 is a marker for certain types of carcinomas such as adenocarcinomas of the colon, transitional cell carcinomas of the bladder and Merkel cell tumors of the skin; sensitive detection of intestinal and gastric foveolar epithelium, urothelial umbrella cells, Merkel cells of epidermis as well as tumors originating therefrom (e.g. primary and metastatic colorectal carcinoma).
PBS containing 0.09% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
KRT20 / CK20 / Cytokeratin 20 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa.