Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Western blot, Immunoprecipitation, Flow Cytometry, ELISA, Functional Assay
Human KIR2DL1 / CD158a
Human (tested or 100% immunogen sequence identity)
Protein G purified
Flow Cytometry (1:50 - 1:100)
Specificity and Use
Human natural killer (NK) cell lysate.
Recognizes KIR2D members of the killer cell immunoglobulin (Ig)-like receptor (KIR) family: CD158a, CD158b and P50.3. Specifically recognizes the long and short forms CD158a and CD158b (KIR2DL, KIR2DS1 and KIR2DS2 respectively) and also p50.3 (KIR2DS4). Reported to have functional activity, activating NK cell cytotoxicity via KIR2DS and inhibiting via KIR2DL forms.
Suitable for use in Flow Cytometry, ELISA. Immunoprecipitation, Western Blot. and Functional Assays. Flow Cytometry: 1:50-1:100. Use 10 ul of the optimal working dilution to label 1E6 cells in 100ul.
PBS, pH 7.2. No preservative added.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
KIR2DL1 Antibody, 47.11 Antibody, Cl-42 Antibody, MHC class I NK cell receptor Antibody, NKAT-1 Antibody, p58 NK receptor CL-42/47.11 Antibody, NKAT Antibody, NKAT1 Antibody, p58.1 Antibody, CD158A Antibody, CD158a antigen Antibody, Killer Ig receptor Antibody, KIR-K64 Antibody, KIR221 Antibody
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2).