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Anti-IL1R1 Antibody (Extracellular Domain, clone 40101) IHC-plus™ LS-B2859

Note: This antibody replaces LS-C83460


Wt. Vol. Conc. Price
50 µg - 0.77 mg/ml Unavailable

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144 IL1R1 Antibodies

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Anti-IL1R1 Antibody (Extracellular Domain, clone 40101) IHC-plus™ LS-B2859
Mouse Monoclonal [clone 40101] (IgG2b) to Human IL1R1
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Immunohistochemistry Image
Anti-IL1R1 Antibody (Extracellular Domain, APC) LS-C184799
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Anti-IL1R1 Antibody (aa474-503) IHC-plus™ LS-B9079
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Mouse Monoclonal [clone 40101] (IgG2b) to Human IL1R1
IHC - Paraffin, ELISA, Radioimmunoassay


Human IL1R1
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [40101]
Protein G purified


  • IHC - Paraffin (10 µg/ml)
  • Radioimmunoassay

  • Western blot

Specificity and Use

IL1R1 antibody was raised against the extracellular domain of the type I human IL-1 receptor.
Extracellular Domain
These antibodies react with cell surface and soluble human IL-1 receptor; Specific epitopes are unknown, but they do partially inhibit (30-50%) binding of one another to IL-1 receptor. They do not block binding of IL-1 to receptor, and they do not cross-react with receptors for human IL-2 or IL-4.
Immunohistochemistry: LS-B2859 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2859 was determined to be 10 ug/ml. ELISA: Can be used as capture reagents or second antibody at a concentration of 5 ug/ml. RIA: Concentrations of 20-30 ng/ml of these antibodies will bind radiolabeled IL-1 receptor in a radioimmunoassay format. Immunocytochemistry: IL-1 receptor can be detected on cultured cells using antibody concentrations of 10-100 ug/ml.


PBS, pH 7.4. Sourced in Ascites.
Long term: -70°C; Short term: -20°C; Avoid freeze-thaw cycles.
For research use only.

About IL1R1

P14778 NM_000877 NP_000868.1

IL1R1 Antibody, Antigen CD121a Antibody, D2S1473 Antibody, IL-1R-1 Antibody, IL-1R-alpha Antibody, IL-1RT-1 Antibody, IL-1RT1 Antibody, IL1R Antibody, IL1RA Antibody, IL1RT1 Antibody, Interleukin receptor 1 Antibody, Interleukin-1 receptor alpha Antibody, Interleukin-1 receptor type 1 Antibody, CD121A Antibody, CD121a antigen Antibody, Interleukin 1 receptor, type I Antibody, Interleukin-1 receptor type I Antibody, Interleukin-1 type i receptor Antibody, p80 Antibody

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits.


Anti-IL1R1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2859 concentration 10 ug/ml.

Requested From: 
Date Requested: 4/25/2017

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