Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 1F12-A6] (IgG1,k) to Human HMOX1 / HO-1
Human, Mouse, Bovine
IHC, ICC, Western blot, Immunoprecipitation, ELISA
Mouse Monoclonal (IgG2b) to Rat HMOX1 / HO-1
Western blot, ELISA
Rat HMOX1 / HO-1
Rat (tested or 100% immunogen sequence identity)
Protein G purified
Western blot (1:1000)
Specificity and Use
HMOX1 / HO-1 antibody was raised against purified native rat heme oxygenase-1.
This affinity purified antibody detects a 32kD protein, corresponding to the apparent molecular mass of HO-1 on SDS-PAGE immunoblots, in samples from rat. Does not recognize HO-2. Reacts similarly to OSA-111, but has the added convenience of a biotin label.
PBS, pH 7.2, 0.09% sodium azide, 50% glycerol
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.