Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
HLA-DRB1 Antibody, DRB1 Antibody, HLA-DR1B Antibody, HLA-DRB Antibody, Human leucocyte antigen DRB1 Antibody, MHC class II antigen DRB1*10 Antibody, MHC class II antigen Antibody, MHC class II antigen DRB1*1 Antibody, HLA-DRB2 Antibody, Lymphocyte antigen DRB1 Antibody, SS1 Antibody
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases.
Formalin-fixed and paraffin-embedded human brain tissue reacted with HLA-DRB1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of HLA-DRB1 Antibody in WiDr cell line lysates (35 ug/lane). HLA-DRB1 (arrow) was detected using the purified antibody.
Western blot of lysates from NCI-H1299, Raji cell line (from left to right), using HLA-DRB1 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
Flow cytometric of widr cells using HLA-DRB1 Antibody (bottom histogram) compared to a negative control cell (top histogram)FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.