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Anti-Histone H4 Antibody (Acetyl-Lys4/Lys7/Lys111/Lys15) LS-C24380

Catalog Size Price
LS-C24380-200 200 µg Unavailable

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100% Guaranteed
Rabbit Polyclonal (IgG)
ICC, Western blot, Immunoprecipitation (applications tested for the base form of this product only)


Histone H4
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Protein A purified


  • ICC (5 - 10 µg/ml)
  • Western blot (0.5 - 2 µg/ml)
  • Immunoprecipitation
  • (applications tested for the base form of this product only)

Specificity and Use

Histone H4 antibody was raised against kLH-conjugated peptide AGG[Ac]KGG[AcK]GMG[AcK]VGA[AcK]RHS-C corresponding to the amino acids 2-19 of Tetrahymena histone H4.
Recognizes acetylated histone H4 of approximately 10kD of human and tetrahymena. Cross-reacts with acetylated histone H2B from Tetrahymena and weakly cross-reacts with acetylated histone H2B from HeLa cells. May cross-react with other acetylated proteins.
Suitable for use in Western Blot, Immunoprecipitation, Immunocytochemistry. Western Blot: 0.5-2 ug/ml will detect acetylated histone H4 in acid-extracted proteins from HeLa cells treated with 5 mM sodium butyrate; a previous lot detected acetylated histone H4 in Tetrahymena macronuclei. Sodium butyrate, an inhibitor of deacetylases, was used to enhance detection of acetylated histone H4. Immunoprecipitation: 5 ug will immunoprecipitate acetylated histone H4 from 500 ug of acid extracted proteins from HeLa cells treated with 5 mM sodium butyrate for 24 hours. Immunocytochemistry: 5-10 ug/ml gave positive nuclear immunostaining in human A431 cells treated with sodium butyrate and fixed with ice-cold 1% paraformaldehyde in PBS. Western Blot Analysis. Acid-extracted proteins from normal HeLa cells and HeLa cells treated with 5 mM sodium butyrate for 24 hours were resolved by electrophoresis, transferred to nitrocellulose and probed with anti-acetylated Histone H4 (1 ug/ml). Proteins were visualized using a goat-anti rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.


0.1 M Tris-glycine, pH 7.4, 0.15 M sodium chloride, 0.05% sodium azide.
For research use only.

About Histone H4

Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail, H4 is a structural component of the nucleosome, and is subject to covalent modification, including acetylation and methylation, which may alter expression of genes located on DNA associated with its parent histone octamer.

Requested From: 
Date Requested: 3/17/2018

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