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Anti-GRM5 / MGLUR5 Antibody (N-Terminus) IHC-plus™ LS-A883
 In Stock - Same day shipping |
Most Popular GRM5 / MGLUR5 Antibodies
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Details
| Human GRM5 / MGLUR5 | |
| Rabbit | |
| Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Chicken (tested or 100% immunogen sequence identity) | |
| Xenopus (at least 90% immunogen sequence identity) | |
| Polyclonal | |
| Unconjugated | |
| Immunoaffinity purified | |
| Unmodified |
Applications
| IHC - Paraffin (5.6 µg/ml) |
Specificity and Use
| GRM5 / MGLUR5 antibody was raised against synthetic 17 amino acid peptide from N-terminal extracellular domain of human GRM5 / MGLUR5. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Bovine, Hamster, Horse, Rabbit, Pig, Turkey, Zebra finch, Chicken, Platypus, Lizard (100%); Xenopus (94%); Opossum, Pufferfish (88%); Zebrafish (82%). | ||
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| N-Terminus | ||
| Human GRM5 / MGLUR5. BLAST analysis of the peptide immunogen showed no homology with other human proteins. | ||
| Immunohistochemistry: LS-A883 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-A883 was determined to be 5.6 ug/ml. |
Packaging
| PBS, less than 0.1% sodium azide. | |
| Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles. | |
| For research use only. |
About GRM5 / MGLUR5
P41594
NM_000842
NP_000833.1
GRM5 Antibody, GPRC1E Antibody, MGLUR5 Antibody, Mglur5b Antibody, MGlu5 Antibody
Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain.
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Requested From:
Date Requested: 8/20/2017
Date Requested: 8/20/2017
