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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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GRM5 / MGLUR5 Antibody (aa1020‑1050) LS‑C100137
MGLUR5 antibody LS-C100137 is an unconjugated rabbit polyclonal antibody to MGLUR5 (GRM5) from human and mouse. Validated for WB.
Catalog
Size
Price
LS-C100137-400
400 µl
Unavailable

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Species: Rat, Mouse
Applications: IHC, ICC, Immunofluorescence, Western blot
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Species: Human
Applications: Western blot, Flow Cytometry, ELISA

Product Description

MGLUR5 antibody LS-C100137 is an unconjugated rabbit polyclonal antibody to MGLUR5 (GRM5) from human and mouse. Validated for WB.
About GRM5 / MGLUR5
Group I of the Metabotropic Glutamate Receptors includes GRM1 and GRM5, receptors that have been shown to activate phospholipase C. Alternative splice variants of GRM5 have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. P41594 NM_000842 NP_000833.1

GRM5 Antibody, GPRC1E Antibody, MGLUR5 Antibody, Mglur5b Antibody, MGlu5 Antibody


Specifications

Target
Human GRM5 / MGLUR5
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Ammonium sulfate precipitation
Modifications
Unmodified
Applications
  • Western blot (1:1000)
Blocking Peptide
LS-E8212 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C100137. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
aa1020-1050
Specificity
This Metabotropic Glutamate Receptor 5 (GPRC1E) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1020-1050 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 5 (GPRC1E).
Presentation
PBS, 0.09% sodium azide
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Images


Western blot

Western blot of Metabotropic Glutamate Receptor 5 (GPRC1E) antibody (C-term T1003) in mouse brain tissue lysates (35 ug/lane). Metabotropic Glutamate Receptor 5 (arrow) was detected using the purified antibody.
Western blot of Metabotropic Glutamate Receptor 5 (GPRC1E) antibody (C-term T1003) in mouse brain tissue lysates (35 ug/lane). Metabotropic Glutamate Receptor 5 (arrow) was detected using the purified antibody.

Western blot

Western blot of Metabotropic Glutamate Receptor 5 (GPRC1E) antibody (C-term T1003) in mouse brain tissue lysates (35 ug/lane). Metabotropic Glutamate Receptor 5 (arrow) was detected using the purified antibody.
Western blot of Metabotropic Glutamate Receptor 5 (GPRC1E) antibody (C-term T1003) in mouse brain tissue lysates (35 ug/lane). Metabotropic Glutamate Receptor 5 (arrow) was detected using the purified antibody.

Western blot

Western blot of Metabotropic Glutamate Receptor 5 (GPRC1E) antibody (C-term T1003) in mouse brain tissue lysates (35 ug/lane). Metabotropic Glutamate Receptor 5 (arrow) was detected using the purified antibody.
Western blot of Metabotropic Glutamate Receptor 5 (GPRC1E) antibody (C-term T1003) in mouse brain tissue lysates (35 ug/lane). Metabotropic Glutamate Receptor 5 (arrow) was detected using the purified antibody.

Western blot

Western blot of Metabotropic Glutamate Receptor 5 (GPRC1E) antibody (C-term T1003) in mouse brain tissue lysates (35 ug/lane). Metabotropic Glutamate Receptor 5 (arrow) was detected using the purified antibody.
Western blot of Metabotropic Glutamate Receptor 5 (GPRC1E) antibody (C-term T1003) in mouse brain tissue lysates (35 ug/lane). Metabotropic Glutamate Receptor 5 (arrow) was detected using the purified antibody.


Requested From: 
Date Requested: 6/21/2018

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