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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Gene Name: | A kinase (PRKA) anchor protein 12 |
Synonyms: | AKAP12, A-kinase anchor protein 12, AKAP-12, AKAP250, AKAP 250, Gravin, Kinase scaffold protein gravin, Myasthenia gravis autoantigen, SSeCKS |
Target Sequences: | NM_005100 NP_005091.2 Q02952 |
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